calsequestrin 1 Antibody (VIIID12): sc-53012

Calsequestrin 1 Antibody (VIIID12) is a mouse monoclonal IgG2b antibody that detects calsequestrin 1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Calsequestrin 1, also known as Calmitin, plays a crucial role in calcium homeostasis within muscle cells by sequestering calcium ions in the lumen of the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Anti-calsequestrin 1 antibody (VIIID12) targets a protein predominantly located in the terminal cisternae of fast-twitch skeletal muscle cells, where calsequestrin 1 helps maintain a high concentration of calcium ions, facilitating efficient calcium release during muscle activation. Proper functioning of calsequestrin 1 is vital for muscle physiology, as dysregulation can lead to impaired muscle function and various cardiac and skeletal muscle disorders. Calsequestrin 1 interacts with ryanodine receptors and is involved in the regulation of calcium signaling pathways, further underscoring its importance in muscle contraction dynamics. Calsequestrin 1 monoclonal antibody (VIIID12) serves as an invaluable tool for researchers studying muscle physiology and related pathologies, providing reliable detection and analysis of this critical protein.

The preferred calsequestrin 1 antibody is calsequestrin 1 Antibody (D-10): sc-137080.