calsequestrin 1 Antibody (4i392): sc-70491

Calsequestrin 1 Antibody (4i392) is a mouse monoclonal IgG2b antibody that detects calsequestrin 1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Calsequestrin 1, also known as Calmitin, plays a crucial role in calcium homeostasis within muscle cells by sequestering calcium ions in the lumen of the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Anti-calsequestrin 1 antibody (4i392) targets a protein predominantly located in the terminal cisternae of fast-twitch skeletal muscle cells, where calsequestrin 1 helps maintain a high concentration of calcium ions, facilitating rapid muscle responses. Proper functioning of calsequestrin 1 is vital for effective excitation-contraction coupling, and any dysregulation can lead to muscle disorders or impaired cardiac function. Calsequestrin 1 also interacts with other proteins such as the ryanodine receptor, Triadin, and Junctin, which are integral to calcium signaling pathways. Calsequestrin 1 monoclonal antibody (4i392) enables researchers to gain insights into the dynamics of calcium handling in muscle tissues, contributing to a better understanding of muscle physiology and related pathologies.

The preferred calsequestrin 1 antibody is calsequestrin 1 Antibody (D-10): sc-137080.