Calgranulin B Antibody (MRP 1H9): sc-53187

Calgranulin B Antibody (MRP 1H9) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Calgranulin B through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Calgranulin B antibody (MRP 1H9) is available in non-conjugated form and conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes. Calgranulin B, also known as MRP14, belongs to the S100 protein family, characterized by EF-hand calcium-binding motifs. Calgranulin B plays a crucial role in inflammatory responses and regulates cellular processes, including cell proliferation and differentiation. Calgranulin B expression occurs in macrophages and epithelial cells, contributing to immune responses and acting as a signaling molecule. Calcium ion binding influences Calgranulin B′s conformation and interaction with other cellular components. Calgranulin B presence at inflammatory sites highlights its role in immune responses and potential as a biomarker for autoimmune disorders and cancer.

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Calgranulin B Antibody (MRP 1H9) References:

1. Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues.  |  Zimmer, DB., et al. 1991. Brain Res Bull. 27: 157-62. PMID: 1742602
2. Monoclonal antibodies to cystic fibrosis antigen.  |  Hayward, C., et al. 1986. J Immunol Methods. 91: 117-22. PMID: 2425000
3. Tissue localization and chromosomal assignment of a serum protein that tracks the cystic fibrosis gene.  |  van Heyningen, V., et al. Nature. 315: 513-5. PMID: 2582274
4. Antitumor effects of calgranulin B internalized in human colon cancer cells.  |  Kim, K., et al. 2016. Oncotarget. 7: 20368-80. PMID: 26933915
5. Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116.  |  Myung, JK., et al. 2017. Oncotarget. 8: 6819-6832. PMID: 28036279
6. Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells.  |  Kim, KH., et al. 2017. PLoS One. 12: e0171232. PMID: 28152021
7. Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues.  |  Wilkinson, MM., et al. 1988. J Cell Sci. 91 (Pt 2): 221-30. PMID: 3267695
8. Developmental and functional studies of parvalbumin and calbindin D28K in hypothalamic neurons grown in serum-free medium.  |  Pfyffer, GE., et al. 1987. J Neurochem. 49: 442-51. PMID: 3298546
9. Developmental appearance of the Ca2+-binding proteins parvalbumin, calbindin D-28K, S-100 proteins and calmodulin during testicular development in the rat.  |  Kägi, U., et al. 1988. Cell Tissue Res. 252: 359-65. PMID: 3383215
10. Increase of skeletal muscle relaxation speed by direct injection of parvalbumin cDNA.  |  Müntener, M., et al. 1995. Proc Natl Acad Sci U S A. 92: 6504-8. PMID: 7604022
11. Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K.  |  Wang, YZ. and Christakos, S. 1995. Mol Endocrinol. 9: 1510-21. PMID: 8584029
12. A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution.  |  Hitomi, J., et al. 1996. J Cell Sci. 109 (Pt 4): 805-15. PMID: 8718672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Calgranulin B Antibody (MRP 1H9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Calgranulin B Antibody (MRP 1H9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Calgranulin B Antibody (MRP 1H9) Specifications

Alternate Product Name: Calgranulin B

Product Clone Name: MRP 1H9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Calgranulin B

Epitope Species: human

Product Reactivity/Detection: Calgranulin B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Calgranulin B Antibody (MRP 1H9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin