Cacna2d1 Antibody (E-10): sc-271697

Cacna2d1 Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cacna2d1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Cacna2d1 antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cacna2d1, also known as calcium channel, voltage-dependent, alpha 2/delta subunit 1, is a crucial component of voltage-dependent calcium channels, which are vital for neurotransmitter release and muscle contraction. Cacna2d1 is primarily located in the plasma membrane of excitable cells, such as those in skeletal muscle and the central nervous system, where Cacna2d1 plays a significant role in regulating calcium influx. Proper functioning of Cacna2d1 is essential for excitation-contraction coupling, as Cacna2d1 influences calcium current density and ensures effective communication between nerve and muscle cells. Notably, Cacna2d1 precursor undergoes proteolytic processing to yield two functional subunits, alpha-2-1 and delta-1, which are linked by disulfide bonds, highlighting the importance of structural integrity for channel function.

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Cacna2d1 Antibody (E-10) References:

1. Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2).  |  Schleithoff, L., et al. 1999. Genomics. 61: 201-9. PMID: 10534405
2. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.  |  Williams, ME., et al. 1992. Neuron. 8: 71-84. PMID: 1309651
3. Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit.  |  Stotz, SC., et al. 2004. J Biol Chem. 279: 3793-800. PMID: 14602720
4. Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels.  |  Chaudhuri, D., et al. 2007. J Gen Physiol. 129: 385-401. PMID: 17438119
5. Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.  |  Ellis, SB., et al. 1988. Science. 241: 1661-4. PMID: 2458626
6. Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.  |  Chintalapudi, SR., et al. 2017. Nat Commun. 8: 1755. PMID: 29176626
7. Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice.  |  Lankford, L., et al. 2024. Exp Eye Res. 241: 109835. PMID: 38373629
8. Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.  |  Gao, S., et al. 2024. iScience. 27: 109351. PMID: 38495825
9. CACNA2D1 regulates the progression and influences the microenvironment of colon cancer.  |  Inoue, H., et al. 2024. J Gastroenterol. 59: 556-571. PMID: 38536483
10. Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families.  |  Iles, DE., et al. 1994. Hum Mol Genet. 3: 969-75. PMID: 7951247
11. Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly.  |  Brust, PF., et al. 1993. Neuropharmacology. 32: 1089-102. PMID: 8107964
12. Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis.  |  Powers, PA., et al. 1994. Genomics. 19: 192-3. PMID: 8188232

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cacna2d1 Antibody (E-10) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Cacna2d1 Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cacna2d1 Antibody (E-10) Specifications

Alternate Product Name: Cacna2d1

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 25-171

Epitope Target: Cacna2d1

Epitope Species: human

Product Reactivity/Detection: Cacna2d1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Cacna2d1 Antibody (E-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin