CA VIII Antibody (C-5): sc-271162
- CA VIII Antibody (C-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a peptide mapping within an internal region of CA VIII of human origin
- recommended for detection of CA VIII of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CA VIII Antibody (C-5) for WB applications. These reagents are now offered in bundles with CA VIII Antibody (C-5) (see ordering information below).
CA VIII Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects carbonic anhydrase VIII (CA VIII) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CA VIII, also known as carbonic anhydrase-related protein VIII, is a unique member of the carbonic anhydrase family that lacks the essential zinc-binding motif required for catalytic activity, which distinguishes CA VIII from other enzymes in this family. Instead of facilitating the reversible hydration of carbon dioxide, CA VIII plays a critical role in synaptic vesicle formation and transport, making CA VIII significant for neuronal function and communication. CA VIII involvement in these processes highlights CA VIII potential impact on synaptic plasticity and overall brain health. Furthermore, emerging research suggests CA VIII may contribute to the invasiveness of non-small cell lung carcinomas and influence the growth of colon cancer cells, indicating CA VIII relevance in cancer biology and potential as a therapeutic target. Anti-CA VIII antibody (C-5) serves as an essential tool for researchers investigating the multifaceted roles of CA VIII in both normal physiology and disease states.
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CA VIII Antibody (C-5) References:
- Effect of carbonic anhydrase-related protein VIII expression on lung adenocarcinoma cell growth. | Lu, SH., et al. 2004. Lung Cancer. 44: 273-80. PMID: 15140539
- Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice. | Jiao, Y., et al. 2005. Genetics. 171: 1239-46. PMID: 16118194
- Carbonic anhydrase-related protein VIII promotes colon cancer cell growth. | Nishikata, M., et al. 2007. Mol Carcinog. 46: 208-14. PMID: 17219437
- Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. | Picaud, SS., et al. 2009. Proteins. 76: 507-11. PMID: 19360879
- Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer. | Aspatwar, A., et al. 2010. Curr Pharm Des. 16: 3264-76. PMID: 20819067
- Carbonic anhydrase-related protein VIII antibodies and paraneoplastic cerebellar degeneration. | Höftberger, R., et al. 2014. Neuropathol Appl Neurobiol. 40: 650-3. PMID: 24446689
- 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. | Jarius, S. and Wildemann, B. 2015. J Neuroinflammation. 12: 166. PMID: 26377085
- 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. | Jarius, S. and Wildemann, B. 2015. J Neuroinflammation. 12: 167. PMID: 26377184
- Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29. | Ando, H., et al. 2018. Proc Natl Acad Sci U S A. 115: 12259-12264. PMID: 30429331
- Case report: Anti-CARPVIII autoantibody-associated mixed dementia. | Hansen, N., et al. 2023. Front Psychiatry. 14: 1133302. PMID: 37215674
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA VIII Antibody (C-5) | sc-271162 | 200 µg/ml | $322.00 | |||
CA VIII Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-537577 | 200 µg Ab; 10 µg BP | $361.00 | |||
CA VIII Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-534881 | 200 µg Ab; 40 µg BP | $361.00 | |||
CA VIII Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-545241 | 200 µg Ab; 20 µg BP | $361.00 | |||
CA VIII (C-5) Neutralizing Peptide | sc-271162 P | 100 µg/0.5 ml | $69.00 |