CA VIII Antibody (B-5): sc-166069

CA VIII Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects carbonic anhydrase VIII (CA VIII) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CA VIII, also known as carbonic anhydrase-related protein VIII, is a unique member of the carbonic anhydrase family that lacks the essential zinc-binding motif required for catalytic activity, which distinguishes CA VIII from other enzymes in this family. Instead of facilitating the reversible hydration of carbon dioxide, CA VIII plays a critical role in synaptic vesicle formation and transport, making CA VIII significant for neuronal function and communication. CA VIII involvement in the invasiveness of non-small cell lung carcinomas and the growth of colon cancer cells highlights CA VIII potential as a biomarker for cancer progression and a target for therapeutic intervention. Anti-CA VIII antibody (B-5) provides a valuable tool for researchers investigating the diverse roles of CA VIII in both normal physiology and disease states, enabling deeper insights into CA VIII function and interactions within cellular environments.

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CA VIII Antibody (B-5) References:

1. Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse.  |  Yan, J., et al. 2007. Neurosci Lett. 413: 196-201. PMID: 17174474
2. Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer.  |  Aspatwar, A., et al. 2010. Curr Pharm Des. 16: 3264-76. PMID: 20819067
3. Phenotypical spectrum of cerebellar ataxia associated with a novel mutation in the CA8 gene, encoding carbonic anhydrase (CA) VIII.  |  Kaya, N., et al. 2011. Am J Med Genet B Neuropsychiatr Genet. 156B: 826-34. PMID: 21812104
4. Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model.  |  Lo, CM., et al. 2018. Arch Biochem Biophys. 641: 50-61. PMID: 29407793
5. Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function.  |  Sanyanga, TA. and Tastan Bishop, Ö. 2020. Int J Mol Sci. 21: PMID: 32316137
6. Novel homozygous variant of carbonic anhydrase 8 gene expanding the phenotype of cerebellar ataxia, mental retardation, and disequilibrium syndrome subtype 3.  |  Paternoster, L., et al. 2020. Am J Med Genet A. 182: 2685-2693. PMID: 32808436
7. Carbonic Anhydrase VIII (CAVIII) Gene Mediated Colorectal Cancer Growth and Angiogenesis through Mediated miRNA 16-5p.  |  Hsieh, M., et al. 2022. Biomedicines. 10: PMID: 35625769
8. Assignment of the gene for human carbonic anhydrase VIII(CA8) to chromosome 8q11-->q12.  |  Bergenhem, NC., et al. 1995. Cytogenet Cell Genet. 71: 299-300. PMID: 7587398
9. Lurching, reeling, waddling and staggering in mice--is carbonic anhydrase (CA) VIII a candidate gene?  |  Kelly, C., et al. 1994. Biochem Soc Trans. 22: 359S. PMID: 7821612
10. Expression of the acatalytic carbonic anhydrase VIII gene, Car8, during mouse embryonic development.  |  Lakkis, MM., et al. 1997. Histochem J. 29: 135-41. PMID: 9147070

The preferred CA VIII antibody is CA VIII Antibody (E-4): sc-166626.