C6ST-1 Antibody (G-9): sc-271696

C6ST-1 Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects C6ST-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). C6ST-1 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Chondroitin 6-sulfotransferase-1 (C6ST-1) is a crucial enzyme that plays a significant role in the sulfation of glycosaminoglycans, specifically chondroitin and keratan sulfate, which are vital for maintaining the structural integrity of the extracellular matrix. This 486 amino acid protein is primarily localized in the Golgi apparatus, where C6ST-1 facilitates the addition of sulfate groups to these polysaccharides, influencing various biological processes such as cell signaling, proliferation, and differentiation. C6ST-1 expression is developmentally controlled, with notable expression persisting into adulthood in the spleen, and C6ST-1 upregulation has been linked to enhanced motility of Schwann cells, which are essential for guiding axons during development and in response to injury. C6ST-1′s ability to modify glycosaminoglycans underscores C6ST-1′s importance in both normal physiological functions and potential pathological conditions, making anti-C6ST-1 antibody (G-9) a valuable tool for researchers studying these processes.

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C6ST-1 Antibody (G-9) References:

1. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing.  |  Uchimura, K., et al. 2004. J Biol Chem. 279: 35001-8. PMID: 15175329
2. Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement.  |  Thiele, H., et al. 2004. Proc Natl Acad Sci U S A. 101: 10155-60. PMID: 15215498
3. The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.  |  de Graffenried, CL. and Bertozzi, CR. 2004. J Biol Chem. 279: 40035-43. PMID: 15220337
4. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes.  |  Gauguet, JM., et al. 2004. Blood. 104: 4104-12. PMID: 15319280
5. Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.  |  Yamada, T., et al. 2004. Biochem J. 384: 567-75. PMID: 15324304
6. Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia.  |  Properzi, F., et al. 2005. Eur J Neurosci. 21: 378-90. PMID: 15673437
7. Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes.  |  Nishimura, M., et al. 2004. Drug Metab Pharmacokinet. 19: 422-9. PMID: 15681896
8. N-linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, Golgi localization, and sulfotransferase activity toward keratan sulfate.  |  Yusa, A., et al. 2006. J Biol Chem. 281: 20393-403. PMID: 16720579
9. Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase.  |  Fukuta, M., et al. 1995. J Biol Chem. 270: 18575-80. PMID: 7629189

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C6ST-1 Antibody (G-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-C6ST-1 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C6ST-1 Antibody (G-9) Specifications

Alternate Product Name: C6ST-1

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-110

Epitope Target: C6ST-1

Epitope Species: human

Product Reactivity/Detection: C6ST-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for C6ST-1 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin