C23 (Nucleolin) Antibody (C-2): sc-515312
- C23 (Nucleolin) Antibody (C-2) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 589-610 within an internal region of C23 of human origin
- recommended for detection of C23 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See C23 (MS-3): sc-8031 for C23 (Nucleolin) antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for C23 (Nucleolin) Antibody (C-2) for WB and IHC(P) applications. These reagents are now offered in bundles with C23 (Nucleolin) Antibody (C-2) (see ordering information below).
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SEE ALSO...
C23 Antibody (C-2) is a mouse monoclonal IgG2a antibody that detects C23 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). C23, also known as nucleolin, is a crucial eukaryotic nucleolar phosphoprotein that plays a significant role in ribosome synthesis and maturation, essential for protein synthesis in all living cells. Anti-C23 antibody (C-2) targets proteins primarily located in dense fibrillar regions of the nucleolus, where C23 interacts with pre-ribosomal RNA during synthesis, influencing RNA processing and ribosomal gene transcription. C23 maintains cellular homeostasis and regulates ribosome production, necessary for cellular growth and proliferation. C23 associates with various proteins, including nucleolar protein B23, and phosphorylation by Cdc2 and casein kinase II leads to nucleolar-to-cytoplasm translocation, highlighting dynamic cellular roles. C23′s interaction with human telomerase reverse transcriptase subunit (TERT) is critical for nucleolar localization of TERT, underscoring importance in telomere maintenance and cellular aging. C23 monoclonal antibody (C-2) serves as an invaluable tool for researchers studying ribosome biogenesis, nucleolar function, and cellular growth regulatory mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C23 Antibody (C-2) | sc-515312 | 200 µg/ml | $322.00 | |||
C23 (Nucleolin) Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-541043 | 200 µg Ab; 10 µg BP | $361.00 | |||
C23 (Nucleolin) Antibody (C-2): m-IgG2a BP-HRP Bundle | sc-547007 | 200 µg Ab; 10 µg BP | $361.00 | |||
C23 (Nucleolin) (C-2) Neutralizing Peptide | sc-515312 P | 100 µg/0.5 ml | $69.00 |