Yes Antibody (2F3E6): sc-130055

c-Yes Antibody (2F3E6) is a mouse monoclonal IgG1 antibody that recognizes c-Yes in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). c-Yes is a crucial member of the Src family of non-receptor tyrosine kinases, which play a significant role in various cellular processes, including cell proliferation, differentiation, motility, and adhesion. The c-Yes protein, encoded by the human c-Yes gene located on chromosome 18p11.31-p11.21, consists of 543 amino acids and shares over 80% homology with c-Src, particularly outside of their unique amino-terminal regions. This high degree of similarity allows c-Yes to participate in similar signaling pathways, but distinct SH3 and SH2 domains provide specificity in substrate binding, which is essential for cellular signaling. c-Yes modulates these pathways as a vital player in oncogenic processes, and understanding c-Yes interactions and regulatory mechanisms is crucial for developing targeted therapies in cancer treatment. Anti-c-Yes antibody (2F3E6) serves as an invaluable tool for researchers investigating c-Yes in various biological contexts, enabling deeper insights into function and potential as a therapeutic target.

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Yes Antibody (2F3E6) References:

1. The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src.  |  Summy, JM., et al. 2003. J Cell Sci. 116: 2585-98. PMID: 12734402
2. Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase: Possible signal transduction in tissue factor up-regulation.  |  Murata, K., et al. 2006. Biochim Biophys Acta. 1762: 835-43. PMID: 16930953
3. Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells.  |  Kuga, T., et al. 2007. Arch Biochem Biophys. 466: 116-24. PMID: 17692281
4. Purification and characterization of a rat liver membrane tyrosine-protein kinase, the possible protooncogene c-yes product, p60c-yes.  |  Azuma, K., et al. 1991. J Biol Chem. 266: 4831-9. PMID: 2002030
5. Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study.  |  Xiao, X., et al. 2014. Am J Physiol Endocrinol Metab. 307: E553-62. PMID: 25117412
6. c-Yes enhances tumor migration and invasion via PI3K/AKT pathway in epithelial ovarian cancer.  |  Jin, Y., et al. 2016. Exp Mol Pathol. 101: 50-7. PMID: 27289010
7. Inhibition of c-Yes induces differentiation of HT-29 human colon cancer stem cells through midbody elongation.  |  Jung, J., et al. 2016. Tissue Eng Regen Med. 13: 261-269. PMID: 30603407
8. Effect of low-intensity pulsed ultrasound on the mineralization of force-treated cementoblasts and orthodontically induced inflammatory root resorption via the Lamin A/C-Yes associated protein axis.  |  Zheng, F., et al. 2024. J Periodontal Res.. PMID: 39095980
9. Differing kinase activity of the c-yes and c-src gene proteins in TPA-induced megakaryocytic differentiation of T-33 and K562 cell lines.  |  Aoki, N., et al. 1995. Res Exp Med (Berl). 195: 39-47. PMID: 7784702
10. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation.  |  Han, NM., et al. 1997. Ann Surg Oncol. 4: 264-8. PMID: 9142389

The preferred Yes antibody is Yes Antibody (C-10): sc-46674.