c-Fos Antibody (4-10G): sc-413

c-Fos Antibody (4-10G) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 1-111 at the N-terminus of human c-Fos, a crucial transcription factor that regulates cellular growth and differentiation. Anti-c-Fos antibody (4-10G) recognizes an epitope within this N-terminal region and demonstrates broad species cross-reactivity, detecting c-Fos, FosB, Fra-1, and Fra-2 proteins in mouse, rat, and human samples through Western blotting (WB) and immunoprecipitation (IP) applications. c-Fos monoclonal antibody (4-10G) is available in non-conjugated form and multiple conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, offering versatility for diverse experimental needs. As a nuclear phosphoprotein encoded by the c-Fos proto-oncogene, c-Fos functions through a sophisticated regulatory mechanism that begins with cellular stimulation by growth factors, cytokines, or stress signals. Once synthesized, c-Fos translocates to the nucleus where c-Fos dimerizes with c-Jun to form the AP-1 transcription factor complex. This nuclear localization proves essential for c-Fos′s ability to access and regulate DNA. The versatility of AP-1 complex formation extends through functional homologs FosB, Fra-1, and Fra-2, which can also participate in these regulatory complexes. Through binding to specific DNA sequences, these AP-1 complexes orchestrate the transcription of target genes crucial for cell proliferation, differentiation, and survival. Through these diverse cellular functions, c-Fos (4-10G) antibody serves as a valuable tool for investigating transcriptional regulation and cellular signaling pathways.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Fos Antibody (4-10G) has 74 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Fos Antibody (4-10G) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Fos Antibody (4-10G) Specifications

Alternate Product Name: c-Fos

Product Clone Name: 4-10G

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-111

Epitope Target: c-Fos

Epitope Species: human

Product Reactivity/Detection: c-Fos, Fos B, Fra-1 and Fra-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 74 citations in various scientific publications

Available Conjugates/Forms for c-Fos Antibody (4-10G): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred c-Fos antibody is c-Fos Antibody (D-1): sc-8047.