c-Fgr Antibody (D-6): sc-74542

c-Fgr Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects c-Fgr p55 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-Fgr (D-6) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. c-Fgr, a member of the Src family of non-receptor tyrosine kinases, plays a crucial role in cellular signaling pathways that regulate essential processes such as cell proliferation, differentiation, and motility. c-Fgr primarily resides in the cytoplasm and can move to the cell membrane, becoming activated in response to various stimuli. This localization to different cellular compartments enables precise regulation of signaling cascades that influence cellular responses to external signals. The human c-Fgr gene encodes a 529 amino acid protein, with tightly controlled activity to prevent aberrant signaling that could lead to oncogenesis. Understanding c-Fgr localization and function remains essential for elucidating its role in health and disease, particularly in cancer research, where Src family kinases are often implicated in tumor progression and metastasis.

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c-Fgr Antibody (D-6) References:

1. Kinases of the Src family: structure and functions.  |  Tatosyan, AG. and Mizenina, OA. 2000. Biochemistry (Mosc). 65: 49-58. PMID: 10702640
2. Src kinase-mediated signaling in leukocytes.  |  Korade-Mirnics, Z. and Corey, SJ. 2000. J Leukoc Biol. 68: 603-13. PMID: 11073097
3. Selected glimpses into the activation and function of Src kinase.  |  Bjorge, JD., et al. 2000. Oncogene. 19: 5620-35. PMID: 11114743
4. SRC family kinases mediate epithelial Na+ channel inhibition by endothelin.  |  Gilmore, ES., et al. 2001. J Biol Chem. 276: 42610-7. PMID: 11560932
5. Regulation of c-fgr messenger RNA levels in U937 cells treated with different modulating agents.  |  Faulkner, L., et al. 1992. Immunology. 76: 65-71. PMID: 1628903
6. The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages.  |  Patel, M., et al. 1991. Pathobiology. 59: 289-92. PMID: 1652975
7. The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization.  |  Knutson, JC. 1990. J Virol. 64: 2530-6. PMID: 2159528
8. Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.  |  Brickell, PM. and Patel, M. 1988. Br J Cancer. 58: 704-9. PMID: 2852026
9. Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family.  |  Tronick, SR., et al. 1985. Proc Natl Acad Sci U S A. 82: 6595-9. PMID: 2995972
10. Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors.  |  Ruzzene, M., et al. 1994. J Biol Chem. 269: 15885-91. PMID: 7515063
11. Specific stimulation of c-Fgr kinase by tyrosine-phosphorylated (poly)peptides--possible implication in the sequential mode of protein phosphorylation.  |  Ruzzene, M., et al. 1997. Eur J Biochem. 245: 701-7. PMID: 9183008
12. Insights into Src kinase functions: structural comparisons.  |  Williams, JC., et al. 1998. Trends Biochem Sci. 23: 179-84. PMID: 9612082

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Fgr Antibody (D-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Fgr Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Fgr Antibody (D-6) Specifications

Alternate Product Name: c-Fgr

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 4-63

Epitope Target: c-Fgr

Epitope Species: mouse

Product Reactivity/Detection: c-Fgr p55

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for c-Fgr Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin