c-Fgr Antibody (B-8): sc-166079

c-Fgr Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-Fgr of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-Fgr (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. c-Fgr, a member of the Src family of non-receptor tyrosine kinases, plays a crucial role in cellular signaling pathways that regulate essential processes such as cell proliferation, differentiation, and motility. c-Fgr is primarily located in the cytoplasm and can translocate to the cell membrane upon activation, which is vital for signal transduction. c-Fgr interaction with various signaling molecules and adaptors at the membrane is essential for the modulation of cellular responses to external stimuli. The human c-Fgr gene encodes a 529 amino acid protein that is structurally characterized by an amino-terminal cell membrane anchor, an SH3 domain, and an SH2 domain, which are critical for regulatory functions. Understanding c-Fgr localization and activation mechanisms is important for elucidating its role in oncogenic processes and potential therapeutic targets in cancer treatment.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

c-Fgr Antibody (B-8) References:

1. Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.  |  Link, DC., et al. 1992. Oncogene. 7: 877-84. PMID: 1373875
2. Diverse biologic properties imparted by the c-fgr proto-oncogene.  |  Sartor, O., et al. 1992. J Biol Chem. 267: 3460-5. PMID: 1737799
3. Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages.  |  Willman, CL., et al. 1991. Blood. 77: 726-34. PMID: 1825181
4. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.  |  Gutkind, JS., et al. 1991. Mol Cell Biol. 11: 1500-7. PMID: 1847500
5. Differential expression and regulation of the c-src and c-fgr protooncogenes in myelomonocytic cells.  |  Willman, CL., et al. 1987. Proc Natl Acad Sci U S A. 84: 4480-4. PMID: 2440024
6. Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells.  |  Yi, TL. and Willman, CL. 1989. Oncogene. 4: 1081-7. PMID: 2674853
7. The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo.  |  Link, DC. and Zutter, M. 1995. Blood. 85: 472-9. PMID: 7812001
8. The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage.  |  Hatakeyama, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 3458-62. PMID: 8159769
9. A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.  |  Agostinis, P., et al. 1996. Eur J Biochem. 236: 548-57. PMID: 8612628
10. Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.  |  Zarn, JA., et al. 1996. Biochem Biophys Res Commun. 225: 384-91. PMID: 8753773

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Fgr Antibody (B-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Fgr Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Fgr Antibody (B-8) Specifications

Alternate Product Name: c-Fgr

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 4-78

Epitope Target: c-Fgr

Epitope Species: human

Product Reactivity/Detection: c-Fgr p55

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for c-Fgr Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred c-Fgr antibody is c-Fgr Antibody (D-6): sc-74542.