C/EBP δ Antibody (C-6): sc-365546

C/EBP δ Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects C/EBP delta protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). C/EBP δ (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C/EBP delta protein plays a crucial role in regulating gene expression, particularly in response to inflammatory signals and during cell type differentiation. C/EBP delta protein is primarily located in the nucleus, functioning as a transcription factor by binding to specific DNA sequences to modulate genes involved in immune responses, metabolism, and cell cycle regulation. Nuclear localization enables C/EBP delta protein to directly influence transcriptional machinery, impacting cellular processes like inflammation and adipogenesis. C/EBP delta protein can form heterodimers with other C/EBP family members, such as C/EBP β, enhancing regulatory capabilities and allowing coordinated response to various physiological stimuli. C/EBP delta protein′s interaction with other transcription factors highlights its significance in maintaining cellular homeostasis and responding to environmental changes.

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C/EBP δ Antibody (C-6) References:

1. Expression pattern of the CCAAT/enhancer-binding proteins C/EBP-alpha, C/EBP-beta and C/EBP-delta in the human placenta.  |  Bamberger, AM., et al. 2004. Virchows Arch. 444: 149-52. PMID: 14691721
2. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.  |  Cao, Z., et al. 1991. Genes Dev. 5: 1538-52. PMID: 1840554
3. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.  |  Williams, SC., et al. 1991. Genes Dev. 5: 1553-67. PMID: 1884998
4. C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in mice.  |  Chen, YH., et al. 2009. Acta Pharmacol Sin. 30: 1138-43. PMID: 19617893
5. CCAAT-enhancer binding protein: a component of a differentiation switch.  |  Umek, RM., et al. 1991. Science. 251: 288-92. PMID: 1987644
6. C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α.  |  Min, Y., et al. 2011. Oncogene. 30: 4901-9. PMID: 21666710
7. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.  |  Birkenmeier, EH., et al. 1989. Genes Dev. 3: 1146-56. PMID: 2792758
8. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.  |  Johnson, PF., et al. 1987. Genes Dev. 1: 133-46. PMID: 2824279
9. Isolation of a recombinant copy of the gene encoding C/EBP.  |  Landschulz, WH., et al. 1988. Genes Dev. 2: 786-800. PMID: 2850264
10. C/EBP-δ positively regulates MDSC expansion and endothelial VEGFR2 expression in tumor development.  |  Min, Y., et al. 2017. Oncotarget. 8: 50582-50593. PMID: 28881585
11. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.  |  Davydov, IV., et al. 1995. Gene. 161: 271-5. PMID: 7665092
12. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.  |  Ramji, DP., et al. 1993. Nucleic Acids Res. 21: 289-94. PMID: 7680115

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C/EBP δ Antibody (C-6) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-C/EBP δ Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C/EBP δ Antibody (C-6) Specifications

Alternate Product Name: CEBPD

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 31-170

Epitope Target: C/EBP δ

Epitope Species: human

Product Reactivity/Detection: C/EBP δ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for C/EBP δ Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred C/EBP δ antibody is C/EBP δ Antibody (D-1): sc-515028.