C/EBP δ Antibody (D-1): sc-515028

C/EBP δ Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects C/EBP δ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). C/EBP δ Antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C/EBP δ, a member of the CCAAT/enhancer-binding protein family, plays a crucial role in regulating gene expression, particularly in response to cellular stress and inflammation. C/EBP δ is primarily located in the nucleus, where C/EBP δ functions as a transcription factor, binding to specific DNA sequences to modulate the expression of genes involved in metabolic processes and immune responses. Nuclear localization of C/EBP δ enables direct interaction with transcriptional machinery and other regulatory proteins, thereby influencing cellular differentiation and proliferation. C/EBP δ can form heterodimers with other C/EBP family members, such as C/EBP β, enhancing regulatory capabilities and allowing for a coordinated response to various physiological stimuli. These multiple partner interactions highlight C/EBP δ′s significance in maintaining cellular homeostasis and responding to environmental changes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

C/EBP δ Antibody (D-1) References:

1. A role for C/EBP delta in human surfactant protein A (SP-A) gene expression.  |  Matlapudi, A., et al. 2002. Biochim Biophys Acta. 1575: 91-8. PMID: 12020823
2. Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells.  |  Dearth, LR. and DeWille, J. 2003. J Biol Chem. 278: 11246-55. PMID: 12554732
3. C/EBP-delta induction by gp130 signaling. Role in transition to myelin gene expressing phenotype in a melanoma cell line model.  |  Kamaraju, AK., et al. 2004. J Biol Chem. 279: 3852-61. PMID: 14600146
4. Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta.  |  Karlsen, JR., et al. 2010. J Biol Chem. 285: 14088-100. PMID: 20220144
5. Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells.  |  Liu, YW., et al. 2010. J Cell Biochem. 110: 1430-8. PMID: 20506344
6. CCAAT/Enhancer Binding Protein-delta (C/EBP-delta) regulates cell growth, migration and differentiation.  |  Yu, X., et al. 2010. Cancer Cell Int. 10: 48. PMID: 21143913
7. The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide.  |  Ramberg, V., et al. 2011. J Neuroinflammation. 8: 34. PMID: 21492414
8. Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.  |  Srivastava, RAK., et al. 2018. Mol Cell Biochem. 449: 167-183. PMID: 29644527
9. Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation.  |  Ray, A. and Ray, BK. 1994. Mol Cell Biol. 14: 4324-32. PMID: 8196668
10. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization.  |  Cleutjens, CB., et al. 1993. Genomics. 16: 520-3. PMID: 8314590

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C/EBP δ Antibody (D-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-C/EBP δ Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C/EBP δ Antibody (D-1) Specifications

Alternate Product Name: CEBPD

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 252-269

Epitope Target: C/EBP δ

Epitope Species: human

Product Reactivity/Detection: C/EBP δ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for C/EBP δ Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred C/EBP δ antibody is C/EBP δ Antibody (C-6): sc-365546.