BVES Antibody (H-4): sc-374082

BVES Antibody (H-4) is a mouse monoclonal IgG1 antibody that detects blood vessel epicardial substance (BVES) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BVES is a crucial transmembrane protein involved in cell-cell interactions and adhesion, particularly at tight junctions, which are essential for maintaining the integrity of epithelial layers. Anti-BVES antibody (H-4) recognizes a unique structure, comprising an extracellular amino-terminus, three transmembrane domains, and a cytoplasmic carboxyl-terminus, which collectively facilitate its role in cellular adhesion and communication. BVES is predominantly expressed in the developing coronary vascular system, including the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme, and vascular smooth muscle cells, where BVES is vital for directing the development of heart, epithelial, and muscle cells during embryogenesis. By accumulating at cell-cell contact points, such as filopodia and cell borders, BVES enhances adhesion prior to the recruitment of E-cadherin, thereby playing a significant role in regulating epithelial integrity during cellular movement and growth. BVES (H-4) antibody is an invaluable tool for researchers studying the dynamics of cell adhesion and the developmental processes of the cardiovascular system.

The preferred BVES antibody is BVES Antibody (E-3): sc-374081.