BVES Antibody (E-3): sc-374081

BVES Antibody (E-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects BVES protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-BVES antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The blood vessel epicardial substance (BVES), also known as Popeye protein 1, is a crucial transmembrane protein involved in cell-cell interactions and adhesion, particularly at tight junctions. BVES structure includes an extracellular amino-terminus, three transmembrane domains, and a cytoplasmic carboxyl-terminus, which are essential for maintaining cellular integrity and facilitating communication between adjacent cells. BVES is predominantly expressed in the developing coronary vascular system, specifically within the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme, and vascular smooth muscle cells, where BVES plays a vital role in directing the development of heart, epithelial, and muscle cells during embryogenesis. BVES accumulates at sites of cell-cell contact, such as filopodia and cell borders, promoting adhesion prior to the arrival of E-cadherin, and BVES is instrumental in regulating epithelial integrity during cell movement and growth, making BVES a significant target for studies related to cardiovascular development and cellular adhesion mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BVES Antibody (E-3) References:

1. bves: A novel gene expressed during coronary blood vessel development.  |  Reese, DE., et al. 1999. Dev Biol. 209: 159-71. PMID: 10208750
2. Bves: prototype of a new class of cell adhesion molecules expressed during coronary artery development.  |  Wada, AM., et al. 2001. Development. 128: 2085-93. PMID: 11493530
3. Developmental expression of Pop1/Bves.  |  Vasavada, TK., et al. 2004. J Histochem Cytochem. 52: 371-7. PMID: 14966204
4. Bves expression during avian embryogenesis.  |  Osler, ME. and Bader, DM. 2004. Dev Dyn. 229: 658-67. PMID: 14991721
5. The Popeye domain-containing gene family.  |  Brand, T. 2005. Cell Biochem Biophys. 43: 95-103. PMID: 16043887
6. Bves modulates epithelial integrity through an interaction at the tight junction.  |  Osler, ME., et al. 2005. J Cell Sci. 118: 4667-78. PMID: 16188940
7. Xbves is a regulator of epithelial movement during early Xenopus laevis development.  |  Ripley, AN., et al. 2006. Proc Natl Acad Sci U S A. 103: 614-9. PMID: 16407138
8. Bves, a member of the Popeye domain-containing gene family.  |  Osler, ME., et al. 2006. Dev Dyn. 235: 586-93. PMID: 16444674
9. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.  |  Parang, B., et al. 2017. Gut. 66: 852-862. PMID: 28389570
10. Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.  |  Zheng, W., et al. 2023. PLoS One. 18: e0287133. PMID: 37347740
11. MBNL1‑AS1 attenuates tumor cell proliferation by regulating the miR‑29c‑3p/BVES signal in colorectal cancer.  |  Chen, WS., et al. 2023. Oncol Rep. 50: PMID: 37711058
12. Coronary artery anomalies. Part I: Recent insights from molecular embryology.  |  von Kodolitsch, Y., et al. 2004. Z Kardiol. 93: 929-37. PMID: 15599567

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BVES Antibody (E-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-BVES Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BVES Antibody (E-3) Specifications

Alternate Product Name: BVES

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-300

Epitope Target: BVES

Epitope Species: human

Product Reactivity/Detection: BVES

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for BVES Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin