BUP-1 Antibody (B-5): sc-393221

BUP-1 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects BUP-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). BUP-1, also known as β-ureidopropionase or N-carbamyl-β-alanine amidohydrolase, plays a crucial role in the catabolism of pyrimidines, specifically catalyzing the hydrolysis of N-carbamyl-β-aminoisobutyric acid to produce β-aminoisobutyric acid, ammonia, and carbon dioxide. This enzymatic activity is vital for the proper degradation of thymine and uracil, and any deficiency in BUP-1 can lead to the accumulation of toxic metabolites such as N-carbamyl-β-aminoisobutyric acid and N-carbamyl-β-alanine, which have been associated with abnormal neurological activity. BUP-1 localizes in the cytoplasm of liver and kidney cells, underscoring BUP-1′s importance in metabolic processes, as these organs are key players in detoxification and metabolic regulation. anti-BUP-1 antibody (B-5) is an essential tool for researchers investigating the biochemical pathways involving pyrimidine metabolism and the potential implications of BUP-1 deficiency in neurological disorders.

The preferred BUP-1 antibody is BUP-1 Antibody (F-11): sc-374066.