BRD3 Antibody (2088C3a): sc-81202

BRD3 Antibody (2088C3a) is a mouse monoclonal IgG1 antibody that detects BRD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-BRD3 antibody (2088C3a) is available as a non-conjugated monoclonal isotype antibody. BRD3 protein plays a crucial role in regulating gene expression and chromatin dynamics, primarily through interaction with acetylated lysines on histones, which is essential for transcriptional activation of various genes involved in cell cycle progression and differentiation. This function is particularly important in cancer biology, as dysregulation of BRD3 can lead to aberrant gene expression patterns that contribute to tumorigenesis. The gene encoding BRD3 is located on chromosome 9q34 and contains two bromodomains, which are critical for interaction with acetylated proteins. Additionally, BRD3 is part of a larger family of bromodomain-containing proteins, including BRD2, BRD4, and BRDT, which are involved in various cellular processes, including transcriptional regulation and chromosomal dynamics during mitosis. The ubiquitous expression of these proteins highlights their fundamental roles in cellular function and development, making BRD3 a significant target for research in both basic biology and therapeutic applications.

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BRD3 Antibody (2088C3a) References:

1. [Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues].  |  Zhou, M., et al. 2003. Ai Zheng. 22: 123-7. PMID: 12600283
2. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells.  |  Kanno, T., et al. 2004. Mol Cell. 13: 33-43. PMID: 14731392
3. Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia.  |  Crowley, T., et al. 2004. Brain Res Dev Brain Res. 149: 93-101. PMID: 15063089
4. Bromodomain containing 2 (Brd2) is expressed in distinct patterns during ovarian folliculogenesis independent of FSH or GDF9 action.  |  Trousdale, RK. and Wolgemuth, DJ. 2004. Mol Reprod Dev. 68: 261-8. PMID: 15112318
5. Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination.  |  Boyer, A., et al. 2004. Biol Reprod. 71: 820-7. PMID: 15128596
6. Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis.  |  Shang, E., et al. 2004. Gene Expr Patterns. 4: 513-9. PMID: 15261828
7. Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.  |  Sinha, A., et al. 2005. Biochem J. 387: 257-69. PMID: 15548137
8. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.  |  Thorpe, KL., et al. 1997. Gene. 200: 177-83. PMID: 9373153

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BRD3 Antibody (2088C3a) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-BRD3 Antibody (2088C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BRD3 Antibody (2088C3a) Specifications

Alternate Product Name: BRD3

Product Clone Name: 2088C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: BRD3

Epitope Species: human

Product Reactivity/Detection: BRD3 isoform 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for BRD3 Antibody (2088C3a): N/A