BRD3 Activators
BRD3 activators, as described in the context of these chemicals, primarily function through the modulation of chromatin structure and histone modifications. These compounds, mostly histone deacetylase inhibitors, increase the acetylation levels of histones. Histone acetylation is a key epigenetic modification that regulates gene expression by altering chromatin structure. When histones are acetylated, the chromatin becomes more open, facilitating the binding of transcription factors and other regulatory proteins, including BRD3.
BRD3, as a member of the BET family, recognizes acetylated lysine residues on histone tails through its bromodomains. The enhanced acetylation induced by these HDAC inhibitors increases the binding affinity of BRD3 to chromatin. This increased binding can modulate the transcriptional activity of BRD3, influencing the expression of genes under its control. The genes regulated by BRD3 are involved in various cellular processes including cell cycle progression, apoptosis, and inflammation. By increasing BRD3's ability to interact with acetylated chromatin, these chemicals can indirectly activate BRD3, leading to alterations in the transcriptional programs governed by it. The mode of action of these compounds underscores the importance of epigenetic modifications in regulating protein interactions and function. By altering the acetylation landscape of chromatin, they provide a means to modulate the activity of chromatin-associated proteins like BRD3. This indirect activation mechanism highlights the interconnected nature of chromatin modifications and gene regulation, wherein changing the histone code can significantly impact the function of key regulatory proteins like BRD3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, acts as a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC, it increases the acetylation of histones, creating a chromatin environment that can facilitate BRD3 binding to acetylated lysines on histones. This enhanced binding can potentially upregulate BRD3 activity in gene regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another HDAC inhibitor. Similar to sodium butyrate, it increases histone acetylation, potentially enhancing BRD3's binding to chromatin. This can lead to an indirect activation of BRD3, influencing gene expression patterns regulated by BRD3. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, an HDAC inhibitor, increases acetylation levels of histones. This can enhance the chromatin binding of BRD3, potentially modulating its activity in regulating gene transcription linked to cell cycle and apoptosis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, another HDAC inhibitor, increases histone acetylation, which may enhance BRD3 binding to acetylated histones. This could indirectly activate BRD3, influencing its role in transcriptional regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is an HDAC inhibitor that can increase histone acetylation. This might enhance the interaction of BRD3 with chromatin, indirectly modulating its role in gene expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin, a cyclic peptide HDAC inhibitor, enhances histone acetylation, which could facilitate the interaction of BRD3 with acetylated histones, potentially modulating its transcriptional regulatory functions. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is an HDAC inhibitor that increases histone acetylation. This may enhance BRD3's chromatin binding and potentially modulate its activity in gene regulation. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585, an HDAC inhibitor, can increase histone acetylation, potentially enhancing BRD3 interaction with chromatin and modulating its role in gene transcription. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275, an HDAC inhibitor, raises histone acetylation levels, which may augment BRD3's binding to chromatin and indirectly influence its transcriptional regulatory activity. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide, a benzamide HDAC inhibitor, increases histone acetylation. This could potentially enhance BRD3's interaction with chromatin, modulating its activity in gene expression regulation. | ||||||