Panobinostat (CAS 404950-80-7)

5.0(1)

Alternate Names: Panobinostat is also known as LBH-589.

Application Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.

CAS 등록번호: 404950-80-7

순도: ≥98%

분자량: 349.43

분자식: C₂₁H₂₃N₃O₂

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

* 참조분석증명서대량의 측정 데이터(함수량포함).

빠른 링크

Western blot analysis of Ac-Histone H4 acetylation in untreated (A)...

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Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC₅₀ ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.

References

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :

Powder

Physical State :

Solid

용해도 :

Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).

저장 :

Store at -20° C

녹는점 :

>115° C (dec.)

비등점 :

608.15° C (Predicted)

굴절률 :

n²⁰_D 1.68 (Predicted)

IC50 :

Histone deacetylase: IC₅₀ = 1.8 nM (Plasmodium falciparum); HDAC1: IC₅₀ = 6.8 nM (human); COLO 205: IC₅₀ = 18 nM (human); PC-3: IC₅₀ = 24 nM (human); A2780: IC₅₀ = 35 nM (human)

Ki 데이타 :

HDAC4: K_i= 0.6 nM (human); HDAC2: K_i= 0.65 nM (human); HDAC6: K_i= 0.7 nM (human); HDAC5: K_i= 0.7 nM (human); HDAC1: K_i= 1 nM (human)

pK Values :

pK_a: 8.71 (Predicted), pK_b: 9.3 (Predicted)

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

RTECS :

UC6378000

PubChem CID :

6918837

MDL Number :

MFCD09833242

SMILES :

CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

SDS(MSDS)다운로드

Region

분석증명서

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Panobinostat (CAS 404950-80-7) 논문정보

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PMID: # 30515817 Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 29778644 Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230 Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976 Cancers (Basel). 12:

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