Panobinostat CAS: 404950-80-7
MF: C21H23N3O2
MW: 349.43

Panobinostat (CAS 404950-80-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 137ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Panobinostat is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Alternate Names: Panobinostat is also known as LBH-589.
Application Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.
CAS 등록번호: 404950-80-7
순도: ≥98%
분자량: 349.43
분자식: C21H23N3O2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.


References

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
저장 :
Store at -20° C
녹는점 :
>115° C (dec.)
비등점 :
608.15° C (Predicted)
굴절률 :
n20D 1.68 (Predicted)
IC50 :
Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki 데이타 :
HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values :
pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
UC6378000
PubChem CID :
6918837
MDL Number :
MFCD09833242
SMILES :
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Panobinostat (CAS 404950-80-7)  논문정보

다른 사용자의 Panobinostat (CAS 404950-80-7)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 5 of 5 합계

PMID: # 30515817  Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 31054975  Ali, I.|Ruiz, DG.|Ni, Z.|Johnson, JR.|Zhang, H.|Li, PC.|Khalid, MM.|Conrad, RJ.|Guo, X.|Min, J.|Greenblatt, J.|Jacobson, M.|Krogan, NJ.|Ott, M.| et al. 2019. Mol. Cell. 74: 1164-1174.e4.

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230  Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976  Cancers (Basel). 12:

인용 1 to 5 of 5 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 112ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.