BRD1 Antibody (2086C1a): sc-81058
- BRD1 Antibody (2086C1a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of BMS1 of human origin
- recommended for detection of BRD1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRD1 Antibody (2086C1a). This work is in progress.
BRD1 Antibody (2086C1a) is a mouse monoclonal IgG1 antibody that detects BRD1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). BRD1, or Bromodomain-containing protein 1, is a 1,058 amino acid protein encoded by the human gene BRD1, which shares homology with Peregrin, a protein believed to act as a transcription factor. This nuclear protein is characterized by the presence of one bromodomain, one PHD-type zinc finger, and one PWWP domain, which are crucial for chromatin interaction and gene expression regulation. The structural features of BRD1, particularly the bromodomain, allow recognition and binding to acetylated lysine residues on histones, playing a significant role in transcriptional activity modulation. This function links chromatin dynamics to gene regulation, influencing processes such as cell differentiation and response to external stimuli. Furthermore, the chromosomal region (22q12-13) that harbors BRD1 has been associated with susceptibility to schizophrenia and bipolar affective disorder, highlighting BRD1′s potential involvement in the pathogenesis of these mental health conditions. BRD1 (2086C1a) antibody serves as an essential tool for researchers investigating BRD1′s role in both cancer and neuropsychiatric disorders.
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BRD1 Antibody (2086C1a) References:
- Support of association between BRD1 and both schizophrenia and bipolar affective disorder. | Nyegaard, M., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 582-591. PMID: 19693800
- The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. | Mishima, Y., et al. 2011. Blood. 118: 2443-53. PMID: 21753189
- Identification of the BRD1 interaction network and its impact on mental disorder risk. | Fryland, T., et al. 2016. Genome Med. 8: 53. PMID: 27142060
- BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide. | Cai, QQ., et al. 2018. Mol Cancer Res. 16: 610-622. PMID: 29453316
- Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. | Gilan, O., et al. 2020. Science. 368: 387-394. PMID: 32193360
- Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. | Rajkumar, AP., et al. 2020. Transl Psychiatry. 10: 239. PMID: 32681022
- Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer. | Wan, C., et al. 2021. Cancer Res. 81: 158-173. PMID: 33158814
- Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping. | Paternoster, V., et al. 2021. Mol Neurobiol. 58: 4495-4505. PMID: 34056693
- Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples. | Li, Z., et al. 2021. Technol Cancer Res Treat. 20: 15330338211039678. PMID: 34482774
- NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer. | Wang, Z., et al. 2024. Sci Transl Med. 16: eado8333. PMID: 39565874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRD1 Antibody (2086C1a) | sc-81058 | 100 µg/ml | $339.00 |