BRD1 Activators
BRD1 activators belong to a class of small molecules that are designed to interact with and modulate the activity of the Bromodomain-containing protein 1 (BRD1). BRD1 is a member of the bromodomain and extraterminal domain (BET) family of proteins, which play crucial roles in epigenetic regulation and gene expression. Bromodomains are protein domains that specifically recognize and bind to acetylated lysine residues on histone proteins, which are essential components of chromatin, the complex structure that packages DNA in the cell nucleus. BRD1, in particular, has been identified as an important regulator of gene transcription and chromatin remodeling processes.
BRD1 activators are designed to selectively bind to the bromodomain of BRD1, leading to a conformational change in the protein that enhances its ability to interact with acetylated histones and other chromatin-associated proteins. This increased binding affinity can result in altered gene expression patterns, as BRD1 is involved in the recruitment of transcriptional machinery to specific gene loci. By modulating BRD1 activity, these activators have the potential to influence various cellular processes that are regulated by BRD1, including cell differentiation, proliferation, and development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain inhibitor, directly activates BRD1 by binding to its bromodomain. This binding disrupts BRD1's interaction with acetylated histones, resulting in increased activity of BRD1 and enhanced gene expression through epigenetic regulation. It acts as a direct activator of BRD1. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
I-BET762, also known as GSK525762A, indirectly promotes the activation of BRD1 by inhibiting bromodomain proteins. By interfering with the binding between bromodomain proteins and acetylated histones, it leads to heightened activity of BRD1 and increased gene expression patterns. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
RVX-208, or Apabetalone, indirectly enhances the activation of BRD1 through epigenetic regulation. It impacts histone modifications, potentially leading to the heightened recruitment of BRD1 to chromatin and increased activity in gene expression. | ||||||