BRCA1 Antibody (GLK-2): sc-56030
- BRCA1 Antibody (GLK-2) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1839-1863 of BRCA1 of human origin
- recommended for detection of BRCA1 of human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine and canine
- See BRCA1 (D-9): sc-6954 for BRCA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRCA1 Antibody (GLK-2). This work is in progress.
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BRCA1 Antibody (GLK-2) is a mouse monoclonal IgM antibody that detects BRCA1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. BRCA1 plays a crucial role in maintaining genomic stability, primarily by participating in the repair of DNA double-strand breaks through homologous recombination. This function is vital because defects in DNA repair mechanisms can lead to the accumulation of genetic mutations, ultimately contributing to the development of various cancers, including breast and ovarian cancer. BRCA1, consisting of 1863 amino acids, features a zinc finger domain that is essential for interactions with other proteins involved in DNA repair and cell cycle regulation. Mutations in BRCA1 can disrupt these interactions, leading to impaired DNA repair and increased susceptibility to tumorigenesis. Anti-BRCA1 antibody (GLK-2) is an invaluable tool for researchers studying the molecular mechanisms of cancer and BRCA1′s role in tumor suppression, providing insights that could inform therapeutic strategies and genetic counseling for at-risk individuals.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRCA1 Antibody (GLK-2) | sc-56030 | 200 µg/ml | $322.00 |