Date published: 2026-1-10

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BRCA1 Inhibitors

BRCA1 inhibitors constitute a well-defined chemical class distinguished by their ability to intricately interact with the BRCA1 protein, a pivotal player in the intricate landscape of cellular processes. These inhibitors are meticulously crafted to engage with specific binding sites or catalytic pockets within the BRCA1 protein, inducing a targeted disruption of its normative functions. This disruption can yield multifaceted effects on diverse cellular pathways, such as DNA repair mechanisms, cell cycle modulation, and chromatin structural dynamics. By deftly manipulating the intricate choreography of molecular interactions orchestrated by BRCA1, these inhibitors hold the promise of unveiling hitherto unexplored facets of cellular functioning.

The structural configuration of BRCA1 inhibitors is inherently tailored to ensure a precision fit within the intricate three-dimensional architecture of the target protein. This specificity enables them to exert a discerning influence on the dynamic equilibrium of molecular events orchestrated by BRCA1, without impinging on the functionality of other vital cellular components. The strategic deployment of BRCA1 inhibitors as research tools can unveil novel insights into the intricate nexus between DNA repair mechanisms and genomic stability. Furthermore, the development of this chemical class represents a significant stride in the realm of molecular pharmacology, illuminating the intricate panorama of cellular machinery. By unraveling the molecular nuances underpinning BRCA1 functionality through the application of these inhibitors, researchers can unravel the complex symphony of molecular events orchestrated by this protein and gain a deeper comprehension of its fundamental contribution to cellular homeostasis.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

LY2606368

1234015-52-1sc-507521
sc-507521A
sc-507521B
sc-507521C
sc-507521D
sc-507521E
5 mg
10 mg
25 mg
100 mg
1 g
10 g
$176.00
$300.00
$500.00
$1900.00
$8000.00
$25000.00
(0)

Being studied for its potential as a CHK1 inhibitor in combination with other therapies for BRCA-mutated cancers. Available for research use only.

2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one

955365-80-7sc-483196
5 mg
$340.00
1
(0)

An inhibitor of the WEE1 kinase, which has shown potential in research studies involving BRCA-mutated cancers. Available for research use only.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$90.00
$212.00
24
(2)

Investigated for its potential to sensitize BRCA-deficient cells to DNA-damaging agents.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Studied for its role in promoting apoptosis in BRCA1-deficient cells.