BRCA1 Antibody (C-11): sc-514797
- BRCA1 Antibody (C-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1564-1863 mapping at the C-terminus of BRCA1 of human origin
- BRCA1 Antibody (C-11) is recommended for detection of BRCA1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BRCA1 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BRCA1 Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with BRCA1 Antibody (C-11) (see ordering information below).
QUICK LINKS
BRCA1 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects BRCA1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). BRCA1 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The BRCA1 gene, identified in 1990 and localized to chromosome 17q, plays a crucial role in maintaining genomic stability and is essential for DNA repair processes, particularly in response to double-strand breaks. This function helps prevent the accumulation of mutations that can lead to cancer, particularly breast and ovarian cancers. Mutations in BRCA1 are implicated in approximately 45% of families with a high incidence of breast cancer and at least 80% of families with early-onset breast and ovarian cancer. BRCA1, consisting of 1863 amino acids, features a zinc finger domain at its amino terminal region, which is important for interaction with other proteins involved in DNA repair. By acting as a tumor suppressor, BRCA1 plays a significant role in regulating cell growth and preventing tumorigenesis, making BRCA1 a critical target for cancer research and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRCA1 Antibody (C-11) | sc-514797 | 200 µg/ml | $322.00 | |||
BRCA1 Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-527944 | 200 µg Ab; 10 µg BP | $361.00 | |||
BRCA1 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-533317 | 200 µg Ab; 20 µg BP | $361.00 | |||
BRCA1 Antibody (C-11) AC | sc-514797 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BRCA1 Antibody (C-11) HRP | sc-514797 HRP | 200 µg/ml | $322.00 | |||
BRCA1 Antibody (C-11) FITC | sc-514797 FITC | 200 µg/ml | $336.00 | |||
BRCA1 Antibody (C-11) PE | sc-514797 PE | 200 µg/ml | $349.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 488 | sc-514797 AF488 | 200 µg/ml | $364.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 546 | sc-514797 AF546 | 200 µg/ml | $364.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 594 | sc-514797 AF594 | 200 µg/ml | $364.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 647 | sc-514797 AF647 | 200 µg/ml | $364.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 680 | sc-514797 AF680 | 200 µg/ml | $364.00 | |||
BRCA1 Antibody (C-11) Alexa Fluor® 790 | sc-514797 AF790 | 200 µg/ml | $364.00 |