bradykinin B1 R Antibody (F-11): sc-518136
- bradykinin B1 R Antibody (F-11) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 230-250 of bradykinin B1 R of human origin
- recommended for detection of bradykinin B1 R of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-bradykinin B1 R Antibody (F-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for bradykinin B1 R Antibody (F-11) for WB applications. This reagent is now offered in a bundle with bradykinin B1 R Antibody (F-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Bradykinin B1 R Antibody (F-11) is a mouse monoclonal IgM antibody that detects bradykinin B1 R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-bradykinin B1 R antibody (F-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The bradykinin B1 receptor plays a crucial role in inflammatory response, as bradykinin B1 R is primarily expressed in response to inflammatory stimuli, such as bacterial lipopolysaccharide and cytokines. This inducible expression allows the body to adapt to inflammatory conditions, making bradykinin B1 R a potential target for therapeutic interventions in inflammatory diseases and pain management. Bradykinin B1 R specifically binds to bradykinin derivatives, which are generated during bradykinin degradation, and bradykinin B1 R activation can lead to various physiological effects, including vasodilation and increased vascular permeability. Understanding bradykinin B1 R function and regulation is essential for developing strategies to modulate bradykinin B1 R activity in pathological conditions, thereby highlighting anti-bradykinin B1 R antibody (F-11) significance in research and therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
bradykinin B1 R Antibody (F-11) References:
- The bradykinin B1 receptor and the central regulation of blood pressure in spontaneously hypertensive rats. | Emanueli, C., et al. 1999. Br J Pharmacol. 126: 1769-76. PMID: 10372819
- Small molecule antagonists of the bradykinin B1 receptor. | Horlick, RA., et al. 1999. Immunopharmacology. 43: 169-77. PMID: 10596850
- Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system. | Wotherspoon, G. and Winter, J. 2000. Neurosci Lett. 294: 175-8. PMID: 11072143
- Small molecule bradykinin B1 receptor antagonists as potential therapeutic agents for pain. | Chen, JJ. and Biswas, K. 2008. Prog Med Chem. 46: 173-204. PMID: 18381126
- The bradykinin B1 receptor antagonist R-954 inhibits Ehrlich tumor growth in rodents. | Fernandes, PD., et al. 2011. Peptides. 32: 1849-54. PMID: 21835216
- Radiolabeled R954 Derivatives for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography. | Kuo, HT., et al. 2017. Mol Pharm. 14: 821-829. PMID: 28094956
- Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice. | Zhang, J., et al. 2018. Cytokine. 108: 71-81. PMID: 29579546
- Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy. | Oliveira, AC., et al. 2023. J Clin Med. 12: PMID: 37109224
- R-954, a bradykinin B1 receptor antagonist, as a potential therapy in a preclinical endometriosis model. | França, PRC., et al. 2024. Peptides. 181: 171294. PMID: 39265809
- Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception. | Tonussi, CR. and Ferreira, SH. 1997. Eur J Pharmacol. 326: 61-5. PMID: 9178656
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
bradykinin B1 R Antibody (F-11) | sc-518136 | 200 µg/ml | $322.00 | |||
bradykinin B1 R Antibody (F-11): m-IgGκ BP-HRP Bundle | sc-551127 | 200 µg Ab; 40 µg BP | $361.00 | |||
bradykinin B1 R Antibody (F-11) AC | sc-518136 AC | 500 µg/ml, 25% agarose | $424.00 | |||
bradykinin B1 R Antibody (F-11) HRP | sc-518136 HRP | 200 µg/ml | $322.00 | |||
bradykinin B1 R Antibody (F-11) FITC | sc-518136 FITC | 200 µg/ml | $336.00 | |||
bradykinin B1 R Antibody (F-11) PE | sc-518136 PE | 200 µg/ml | $349.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 488 | sc-518136 AF488 | 200 µg/ml | $364.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 546 | sc-518136 AF546 | 200 µg/ml | $364.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 594 | sc-518136 AF594 | 200 µg/ml | $364.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 647 | sc-518136 AF647 | 200 µg/ml | $364.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 680 | sc-518136 AF680 | 200 µg/ml | $364.00 | |||
bradykinin B1 R Antibody (F-11) Alexa Fluor® 790 | sc-518136 AF790 | 200 µg/ml | $364.00 |