Date published: 2026-4-23

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bradykinin B1 R Activators

Bradykinin B1 R activators are compounds that activate the B1 receptor (B1R) subtype of the bradykinin receptors. These receptors are part of the G-protein coupled receptor (GPCR) family, which are integral membrane proteins responsible for mediating the cellular responses to a wide range of stimuli. The bradykinin B1 receptor, in particular, is distinguished from the B2 receptor by its patterns of expression and its functional responses to certain ligands. While the B2 receptor is constitutively expressed under normal physiological conditions and responds to bradykinin itself, the B1 receptor's expression is typically induced under pathological conditions, especially those involving inflammation or tissue injury. Therefore, bradykinin B1 R activators specifically target and activate the B1 receptor, initiating a cascade of intracellular events leading to various physiological responses. The bradykinin system, which includes the B1 and B2 receptors, plays a pivotal role in numerous physiological processes. Activation of the bradykinin receptors can lead to vasodilation, increased vascular permeability, modulation of pain perception, and regulation of salt and water balance, among others. Kinins, which are peptides formed from the precursor kininogens by the action of kallikreins, are natural ligands for these receptors. Des-Arg9-bradykinin and des-Arg10-kallidin are the primary endogenous ligands for the B1 receptor. However, the exact effects of bradykinin B1 R activators will depend on the specific context in which they are acting, including tissue type, the physiological state of the organism, and the presence of other interacting molecules or signaling pathways. Overall, understanding the bradykinin B1 R activators and the broader bradykinin system is essential for a comprehensive grasp of various physiological processes and responses.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Enalaprilat dihydrate

84680-54-6sc-205668
sc-205668A
10 mg
50 mg
$180.00
$680.00
(0)

Enalaprilat dihydrate exhibits a unique interaction with bradykinin B1 receptors, characterized by its ability to stabilize receptor conformation and enhance ligand binding affinity. This compound's hydrophilic nature facilitates effective solvation, promoting optimal molecular interactions. Its kinetic behavior indicates a rapid association and dissociation rate, allowing for dynamic modulation of receptor activity. The dihydrate form contributes to its stability, influencing the overall pharmacodynamics within biological systems.

Bradykinin Fragment 1-8 acetate salt

15958-92-6sc-300299
5 mg
$101.00
2
(0)

Bradykinin Fragment 1-8 acetate salt selectively engages with bradykinin B1 receptors, promoting a distinct conformational shift that enhances receptor activation. Its structural composition allows for specific hydrogen bonding and electrostatic interactions, facilitating a robust signaling cascade. The fragment's stability in solution is influenced by its acetate moiety, which aids in maintaining its bioactivity. Additionally, its rapid kinetics enable swift modulation of receptor responses, underscoring its dynamic role in cellular signaling pathways.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$96.00
$160.00
$240.00
$405.00
26
(1)

Capsaicin activates TRPV1 channels and can modulate inflammatory responses. This might result in B1R upregulation as part of a broader response to nociceptive stimuli.

Zofenoprilat Sodium Salt

1329569-13-2sc-220411
1 mg
$374.00
(0)

Zofenoprilat Sodium Salt exhibits a unique affinity for bradykinin B1 receptors, initiating a cascade of intracellular signaling through specific allosteric modulation. Its ionic interactions enhance receptor-ligand binding, promoting a conformational change that amplifies downstream effects. The compound's solubility characteristics facilitate effective distribution in biological systems, while its kinetic profile allows for prompt engagement with target pathways, highlighting its intricate role in cellular communication.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol possesses anti-inflammatory properties. It might enhance B1R expression as a part of modulating the inflammatory pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, known for its anti-inflammatory effects, might induce B1R expression by modulating inflammation-related signaling pathways.

Thalidomide

50-35-1sc-201445
sc-201445A
100 mg
500 mg
$111.00
$357.00
8
(0)

Thalidomide has immunomodulatory effects. It could influence B1R expression as a part of broader modulation of immune responses.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Sulforaphane, found in cruciferous vegetables, has been linked to modulating inflammation, which might influence B1R expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid with anti-inflammatory properties, could modulate B1R expression as part of its mechanism of action on inflammatory pathways.

Berberine

2086-83-1sc-507337
250 mg
$92.00
1
(0)

Berberine might enhance B1R expression as part of its broader modulatory effects.