BMPR-IA Antibody (C-7): sc-518037

BMPR-IA Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Bone morphogenetic protein receptor type 1A (BMPR1A) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-BMPR1A antibody (C-7) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. BMPR1A plays a crucial role in bone and cartilage development as a key component of the bone morphogenetic protein (BMP) signaling pathway, essential for cellular processes like proliferation, differentiation, and apoptosis. BMPR1A monoclonal antibody (C-7) targets receptors primarily located on the cell surface, where BMPR1A interacts with BMPs to initiate intracellular signaling cascades that influence gene expression and cellular behavior. This localization enables rapid response to extracellular signals, modulating developmental processes and tissue homeostasis. BMPR1A forms heteromeric complexes with BMPR-IB and BMPR-II, enhancing BMP signaling specificity and efficacy, which highlights BMPR1A′s importance in maintaining normal physiological functions and potential implications in cancer and bone disorders.

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BMPR-IA Antibody (C-7) References:

1. Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3.  |  Gaussin, V., et al. 2002. Proc Natl Acad Sci U S A. 99: 2878-83. PMID: 11854453
2. Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways.  |  Nohe, A., et al. 2003. J Cell Sci. 116: 3277-84. PMID: 12829744
3. Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation.  |  Pellegrini, M., et al. 2003. J Cell Sci. 116: 3363-72. PMID: 12857787
4. Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect.  |  Sun, J., et al. 2007. Biochem Biophys Res Commun. 360: 238-43. PMID: 17588538
5. The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors.  |  Lee, NY., et al. 2009. Mol Biol Cell. 20: 4362-70. PMID: 19726563
6. Mutually inductive interactions between the lens and retina require ALK3 functions during mouse embryonic development.  |  Zhao, Q., et al. 2012. Int J Ophthalmol. 5: 119-24. PMID: 22762034
7. Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation.  |  Briggs, LE., et al. 2013. Circ Res. 112: 1420-32. PMID: 23584254
8. The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo.  |  Traeger, L., et al. 2018. Commun Biol. 1: 65. PMID: 30271947
9. Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.  |  Wang, CY., et al. 2020. Blood. 135: 453-456. PMID: 31800957
10. ALK3-SMAD1/5 Signaling Mediates the BMP2-Induced Decrease in PGE2 Production in Human Endometrial Stromal Cells and Decidual Stromal Cells.  |  Zhang, Y., et al. 2020. Front Cell Dev Biol. 8: 573028. PMID: 33043005

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMPR-IA Antibody (C-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BMPR-IA Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMPR-IA Antibody (C-7) Specifications

Alternate Product Name: Bone morphogenetic protein receptor type 1A (BMPR1A)

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 41-64

Epitope Target: BMPR-IA

Epitope Species: human

Product Reactivity/Detection: BMPR-IA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BMPR-IA Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin

The preferred BMPR-IA antibody is BMPR-IA Antibody (7K7): sc-134285.