BMPR-IA Antibody (7K7): sc-134285

BMPR-IA Antibody (7K7) is a mouse monoclonal IgG2a antibody that detects BMPR-IA protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BMPR-IA antibody (7K7) is available as a non-conjugated format. BMPR-IA protein, also known as ALK3, plays a crucial role in the bone morphogenetic protein (BMP) signaling pathway, which is essential for various biological processes, including embryonic development, tissue homeostasis, and repair mechanisms. BMPR-IA protein is primarily located on the cell membrane, where BMPR-IA functions as a type I receptor that forms a signaling complex with type II receptors, such as BMPR-II. The interaction between these receptors is vital for the transduction of BMP signals, which regulate gene expression and influence cell differentiation and morphogenesis. Dysregulation of BMPR-IA signaling has been implicated in various pathologies, including cancer and fibrotic diseases, making BMPR-IA an important target for therapeutic intervention. Additionally, BMPR-IA protein interacts with other proteins in the BMP signaling pathway, further emphasizing BMPR-IA′s significance in cellular communication and function.

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BMPR-IA Antibody (7K7) References:

1. Generation of Bmpr/Alk3 conditional knockout mice.  |  Mishina, Y., et al. 2002. Genesis. 32: 69-72. PMID: 11857780
2. Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors.  |  Nascimento, MA., et al. 2017. Arch Oral Biol. 73: 223-229. PMID: 27780042
3. ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2.  |  Traeger, L., et al. 2018. Free Radic Biol Med. 129: 127-137. PMID: 30227271
4. Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration.  |  Guevara-Garcia, A., et al. 2022. J Cell Biol. 221: PMID: 36205720
5. Multiple roles of ALK3 in osteoarthritis.  |  Ruan, X., et al. 2023. Bone Joint Res. 12: 397-411. PMID: 37394235
6. Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury.  |  Marañón, P., et al. 2024. Redox Biol. 71: 103088. PMID: 38401290
7. Cloning and characterization of a human type II receptor for bone morphogenetic proteins.  |  Rosenzweig, BL., et al. 1995. Proc Natl Acad Sci U S A. 92: 7632-6. PMID: 7644468
8. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.  |  Liu, F., et al. 1995. Mol Cell Biol. 15: 3479-86. PMID: 7791754
9. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.  |  ten Dijke, P., et al. 1994. J Biol Chem. 269: 16985-8. PMID: 8006002
10. Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.  |  Yamada, N., et al. 1996. Br J Cancer. 73: 624-9. PMID: 8605097
11. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain.  |  Söderström, S., et al. 1996. Cell Tissue Res. 286: 269-79. PMID: 8854897
12. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament.  |  Yonemori, K., et al. 1997. Am J Pathol. 150: 1335-47. PMID: 9094990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMPR-IA Antibody (7K7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BMPR-IA Antibody (7K7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMPR-IA Antibody (7K7) Specifications

Alternate Product Name: Bone morphogenetic protein receptor type 1A (BMPR1A)

Product Clone Name: 7K7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 1-533

Epitope Target: BMPR-IA

Epitope Species: human

Product Reactivity/Detection: BMPR-IA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BMPR-IA Antibody (7K7): N/A