BMP2K Antibody (E-8): sc-514681
- BMP2K Antibody (E-8) is a mouse monoclonal IgG2a κ BMP2K antibody, cited in 0 publications, provided at 200 µg/ml
- raised against amino acids 969-1161 mapping at the C-terminus of BMP2K of human origin
- BMP2K Antibody (E-8) is recommended for detection of BMP2K of human origin by WB, IP, IF and ELISA
- Anti-BMP2K Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BMP2K Antibody (E-8) for WB applications. These reagents are now offered in bundles with BMP2K Antibody (E-8) (see ordering information below).
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BMP2K Antibody (E-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects BMP2K of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP2K (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMP2K, also known as BMP2 inducible kinase or BIKE, is a 1,161 amino acid nuclear protein that plays a crucial role in osteoblast differentiation and bone formation. BMP2K belongs to the serine/threonine protein kinase family and contains a single protein kinase domain, which is essential for function. BMP2K catalyzes the ATP-dependent phosphorylation of bone morphogenic proteins (BMPs), which are vital for proper cartilage and bone development. The phosphorylation of these proteins is a key regulatory mechanism in various cellular processes, including cell division and apoptosis. BMP2K′s activity is particularly important in signaling pathways that mediate bone growth and cellular differentiation, making BMP2K a significant target for research in bone-related diseases. Additionally, three isoforms of BMP2K exist due to alternative splicing, which may contribute to functional diversity and regulatory mechanisms in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BMP2K Antibody (E-8) References:
- Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. | Kearns, AE., et al. 2001. J Biol Chem. 276: 42213-8. PMID: 11500515
- BMP signaling pathways in cartilage and bone formation. | Hoffmann, A. and Gross, G. 2001. Crit Rev Eukaryot Gene Expr. 11: 23-45. PMID: 11693963
- Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells. | Arikawa, T., et al. 2004. J Cell Physiol. 200: 400-6. PMID: 15254968
- BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study. | Medici, M., et al. 2006. J Bone Miner Res. 21: 845-54. PMID: 16753015
- Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. | Chen, M., et al. 2008. J Cell Sci. 121: 1455-65. PMID: 18397998
- BMP signaling dynamics in embryonic orofacial tissue. | Mukhopadhyay, P., et al. 2008. J Cell Physiol. 216: 771-9. PMID: 18446813
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMP2K Antibody (E-8) | sc-514681 | 200 µg/ml | $316.00 | |||
BMP2K Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-531192 | 200 µg Ab; 10 µg BP | $354.00 | |||
BMP2K Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-524812 | 200 µg Ab, 40 µg BP | $354.00 | |||
BMP2K Antibody (E-8): m-IgG2a BP-HRP Bundle | sc-547721 | 200 µg Ab; 10 µg BP | $354.00 | |||
BMP2K Antibody (E-8) AC | sc-514681 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BMP2K Antibody (E-8) HRP | sc-514681 HRP | 200 µg/ml | $316.00 | |||
BMP2K Antibody (E-8) FITC | sc-514681 FITC | 200 µg/ml | $330.00 | |||
BMP2K Antibody (E-8) PE | sc-514681 PE | 200 µg/ml | $343.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 488 | sc-514681 AF488 | 200 µg/ml | $357.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 546 | sc-514681 AF546 | 200 µg/ml | $357.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 594 | sc-514681 AF594 | 200 µg/ml | $357.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 647 | sc-514681 AF647 | 200 µg/ml | $357.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 680 | sc-514681 AF680 | 200 µg/ml | $357.00 | |||
BMP2K Antibody (E-8) Alexa Fluor® 790 | sc-514681 AF790 | 200 µg/ml | $357.00 |