BMP-9 Antibody (H-6): sc-515256
- BMP-9 Antibody (H-6) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 71-149 mapping within an internal region of BMP-9 of mouse origin
- recommended for detection of BMP-9 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BMP-9 Antibody (H-6) for WB applications. These reagents are now offered in bundles with BMP-9 Antibody (H-6) (see ordering information below).
BMP-9 Antibody (H-6) is a mouse monoclonal IgG2b antibody that detects bone morphogenic protein-9 (BMP-9) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-9 is a crucial member of the transforming growth factor-beta (TGF-beta) superfamily, primarily involved in tissue morphogenesis, particularly in bone and connective tissue development. BMP-9 interacts with specific receptors on liver cells, such as HepG2, where BMP-9 stimulates cell proliferation and plays a vital role in regulating blood glucose levels—an effect distinct from TGF-beta. Research indicates that BMP-9 administration or BMP-9 encoding adenoviral vectors can enhance bone regeneration in ex vivo settings and immune-deficient animal models. This multifaceted functionality of BMP-9 underscores BMP-9′s potential as a target for therapeutic interventions in bone-related disorders and metabolic diseases, making anti-BMP-9 antibody (H-6) an invaluable tool for researchers exploring these critical biological processes.
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BMP-9 Antibody (H-6) References:
- BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity. | Kuo, MM., et al. 2014. Biomaterials. 35: 3172-9. PMID: 24439409
- Collagen gels for delivery of bioactive peptide derived from BMP-9. | Park, K. 2014. J Control Release. 182: 121. PMID: 24784784
- Regulatory role of BMP-9 in steroidogenesis by rat ovarian granulosa cells. | Hosoya, T., et al. 2015. J Steroid Biochem Mol Biol. 147: 85-91. PMID: 25527306
- LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling. | Daigang, L., et al. 2016. Exp Cell Res. 341: 54-60. PMID: 26794904
- BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity. | Kim, S., et al. 2016. Biochim Biophys Acta. 1862: 1237-46. PMID: 27085971
- BMP-9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa-adenoma-adenocarcinoma sequence and is associated with colorectal cancer prognosis. | Fan, Y., et al. 2020. Oncol Lett. 19: 271-282. PMID: 31897139
- BMP-9 downregulates StAR expression and progesterone production by activating both SMAD1/5/8 and SMAD2/3 signaling pathways in human granulosa-lutein cells obtained from gonadotropins induced ovarian cycles. | Fang, L., et al. 2021. Cell Signal. 86: 110089. PMID: 34265413
- Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction. | Kawecki, F., et al. 2022. Int J Mol Sci. 23: PMID: 35328724
- Effect of Mesenchymal Stem Cells Overexpressing BMP-9 Primed with Hypoxia on BMP Targets, Osteoblast Differentiation and Bone Repair. | Paz, JERM., et al. 2023. Biology (Basel). 12: PMID: 37627031
- Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10. | Schwartze, TA., et al. 2025. J Mol Biol. 437: 168935. PMID: 39793884
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMP-9 Antibody (H-6) | sc-515256 | 200 µg/ml | $322.00 | |||
BMP-9 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-536433 | 200 µg Ab; 40 µg BP | $361.00 | |||
BMP-9 Antibody (H-6): m-IgG2b BP-HRP Bundle | sc-549543 | 200 µg Ab; 10 µg BP | $361.00 |