BMAL2 Antibody (C-7): sc-376287
- BMAL2 Antibody (C-7) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 417-468 mapping near the C-terminus of BMAL2 of mouse origin
- Anti-BMAL2 Antibody (C-7) is recommended for detection of BMAL2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BMAL2 Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-376287 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BMAL2 Antibody (C-7). This work is in progress.
QUICK LINKS
BMAL2 Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects BMAL2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMAL2 (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMAL2, also known as ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2), MOP9, CLIF, or PASD9, is a 636 amino acid protein that plays a crucial role in the regulation of circadian rhythms. BMAL2 is primarily localized in the nucleus, where BMAL2 interacts with other core oscillator proteins to activate transcription of target genes. BMAL2 contains one basic helix-loop-helix (bHLH) domain, one PAS-associated C-terminal (PAC) domain, and two PAS (PER-ARNT-SIM) domains, which are essential for function in circadian regulation. BMAL2′s ability to bind to the E-box element (3′-CACGTG-5′) of target DNA is vital for inducing transcription, thereby influencing various physiological processes that follow a circadian pattern. Additionally, multiple isoforms of BMAL2, resulting from alternative splicing, add complexity to regulatory functions, making BMAL2 an important target for studies related to circadian biology and implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BMAL2 Antibody (C-7) References:
- The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. | Hogenesch, JB., et al. 2000. J Neurosci. 20: RC83. PMID: 10864977
- CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. | Maemura, K., et al. 2000. J Biol Chem. 275: 36847-51. PMID: 11018023
- Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation. | Okano, T., et al. 2001. Genes Cells. 6: 825-36. PMID: 11554928
- Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. | Schoenhard, JA., et al. 2002. Am J Physiol Cell Physiol. 283: C103-14. PMID: 12055078
- Molecular circadian rhythms in central and peripheral clocks in mammals. | Dardente, H. and Cermakian, N. 2007. Chronobiol Int. 24: 195-213. PMID: 17453843
- Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. | Shi, J., et al. 2008. Am J Med Genet B Neuropsychiatr Genet. 147B: 1047-55. PMID: 18228528
- Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene. | Onishi, Y., et al. 2008. Mol Cell Biol. 28: 3477-88. PMID: 18332112
- Genetic differences in human circadian clock genes among worldwide populations. | Ciarleglio, CM., et al. 2008. J Biol Rhythms. 23: 330-40. PMID: 18663240
- Increased sensitivity of the circadian system to temporal changes in the feeding regime of spontaneously hypertensive rats - a potential role for Bmal2 in the liver. | Polidarová, L., et al. 2013. PLoS One. 8: e75690. PMID: 24086613
- Regulation of the Neuroligin-1 Gene by Clock Transcription Factors. | Hannou, L., et al. 2018. J Biol Rhythms. 33: 166-178. PMID: 29671709
- Circadian rhythms affect bone reconstruction by regulating bone energy metabolism. | Luo, B., et al. 2021. J Transl Med. 19: 410. PMID: 34579752
- ARNTL2 facilitates bladder cancer progression through potentiating ENO1-mediated glycolysis in a SLC31A1-independent and -dependent manner. | Wang, J., et al. 2024. Life Sci. 355: 122974. PMID: 39147318
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMAL2 Antibody (C-7) | sc-376287 | 200 µg/ml | $322.00 | |||
BMAL2 Antibody (C-7) X | sc-376287 X | 200 µg/0.1 ml | $322.00 | |||
BMAL2 Antibody (C-7) AC | sc-376287 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BMAL2 Antibody (C-7) HRP | sc-376287 HRP | 200 µg/ml | $322.00 | |||
BMAL2 Antibody (C-7) FITC | sc-376287 FITC | 200 µg/ml | $336.00 | |||
BMAL2 Antibody (C-7) PE | sc-376287 PE | 200 µg/ml | $349.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 488 | sc-376287 AF488 | 200 µg/ml | $364.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 546 | sc-376287 AF546 | 200 µg/ml | $364.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 594 | sc-376287 AF594 | 200 µg/ml | $364.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 647 | sc-376287 AF647 | 200 µg/ml | $364.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 680 | sc-376287 AF680 | 200 µg/ml | $364.00 | |||
BMAL2 Antibody (C-7) Alexa Fluor® 790 | sc-376287 AF790 | 200 µg/ml | $364.00 |