BMAL2 Antibody (C-11): sc-365469

BMAL2 Antibody (C-11) is a mouse monoclonal IgG2b lambda antibody that detects BMAL2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BMAL2 (C-11) antibody is available as a non-conjugated anti-BMAL2 monoclonal isotype antibody. BMAL2 protein, also known as ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2), MOP9, CLIF, or PASD9, is a crucial 636 amino acid protein that plays a significant role in the regulation of circadian rhythms. BMAL2 is primarily localized in the nucleus, where BMAL2 contains one basic helix-loop-helix (bHLH) domain, one PAS-associated C-terminal (PAC) domain, and two PER-ARNT-SIM (PAS) domains. BMAL2 expression is notably high in the placenta and brain, with lower levels found in the liver, thymus, heart, lung, and kidney. As a key component of the circadian core oscillator, BMAL2 interacts with other proteins to activate the transcription of target genes by binding to the E-box element (3′-CACGTG-5′) of target DNA, thereby inducing transcription. BMAL2′s importance in maintaining circadian rhythms underscores potential implications in various physiological processes and disorders related to circadian disruption. Additionally, multiple isoforms of BMAL2 arise from alternative splicing events, which may contribute to functional diversity and regulatory mechanisms within the cell.

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BMAL2 Antibody (C-11) References:

1. Overexpression of SSH1 in gastric adenocarcinoma and its correlation with clinicopathological features.  |  Daryabari, SS., et al. 2018. J Gastrointest Oncol. 9: 728-733. PMID: 30151269
2. PKCδ stimulates macropinocytosis via activation of SSH1-cofilin pathway.  |  Singla, B., et al. 2019. Cell Signal. 53: 111-121. PMID: 30261270
3. [Expression and clinical significance of SSH1 in gastrointestinal stromal tumors].  |  Maimaitiaili, M., et al. 2019. Zhonghua Yi Xue Za Zhi. 99: 754-757. PMID: 30884629
4. Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis.  |  Fukuda, R., et al. 2019. Dev Cell. 51: 62-77.e5. PMID: 31495694
5. Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis.  |  Luo, X., et al. 2020. Cell Biosci. 10: 113. PMID: 32983407
6. Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes.  |  Sousa-Squiavinato, ACM., et al. 2021. Cancer Cell Int. 21: 69. PMID: 33482809
7. A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon.  |  Cohen, N., et al. 2023. EMBO J. 42: e113385. PMID: 37073826
8. Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth.  |  Ramos-Alvarez, I., et al. 2023. Front Physiol. 14: 1147572. PMID: 37138671
9. Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.  |  Lai, SW., et al. 2023. Aging (Albany NY). 15: 11033-11051. PMID: 37837551
10. Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.  |  Cai, N., et al. 2024. Gut. 73: 985-999. PMID: 38123979

The preferred BMAL2 antibody is BMAL2 Antibody (C-7): sc-376287.