Blood Group Lewis a Antibody (T174): sc-59469

Blood Group Lewis a Antibody (T174) is a mouse monoclonal IgG1 antibody that detects Blood Group Lewis a in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Blood Group Lewis a is a crucial carbohydrate determinant found on both glycolipids and glycoproteins, playing a significant role in cell-cell interactions and biological recognition processes. Blood Group Lewis a (T174) antibody recognizes carbohydrates on cell surfaces vital for mediating adhesion between cells, particularly in hematopoietic lineages, where Blood Group Lewis a influences the recruitment of cell adhesion molecules and facilitates proper cell trafficking. The fucosyltransferases, which are responsible for the synthesis of Blood Group Lewis a, catalyze the transfer of fucose to specific sugar acceptors, thereby generating a unique carbohydrate profile that is essential for physiological functions such as immune response and inflammation. Blood Group Lewis a′s ability to modulate cell adhesion is particularly important in selectin-mediated interactions, which are critical for leukocyte rolling and migration during immune responses. Anti-Blood Group Lewis a antibody (T174) serves as an invaluable tool for researchers studying cell adhesion mechanisms and the role of glycosylation in health and disease.

The preferred Blood Group Lewis a antibody is Blood Group Lewis a Antibody (7LE): sc-51512.