Blood Group Lewis a Antibody (7LE): sc-51512

Blood Group Lewis a Antibody (7LE) is a mouse monoclonal IgG1 kappa light chain antibody that detects Blood Group Lewis a protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Blood Group Lewis a (7LE) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Blood Group Lewis a protein plays a crucial role in cell-cell interactions and is a key component of carbohydrate determinants found on glycolipids and glycoproteins. Blood Group Lewis a presence on cell surfaces is vital for mediating biological recognition processes, particularly in immune responses and cellular adhesion. Blood Group Lewis a structure, characterized by specific glycosylation patterns, influences how cells interact with one another and their environment, impacting processes such as leukocyte trafficking and inflammation. Blood Group Lewis a antigen fucosylation is particularly important, as this modification facilitates selectin binding, which guides white blood cell movement to sites of injury or infection. Understanding Blood Group Lewis a functional implications and interactions can provide insights into various physiological and pathological processes, making anti-Blood Group Lewis a antibody (7LE) an essential tool for researchers studying cell adhesion and immune responses.

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Blood Group Lewis a Antibody (7LE) References:

1. Alteration of sialyl Lewis epitope expression in pterygium.  |  Creuzot-Garcher, C., et al. 1999. Invest Ophthalmol Vis Sci. 40: 1631-6. PMID: 10393028
2. Expression and transcriptional regulation of the human alpha1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines.  |  Taniguchi, A., et al. 2000. Biochem Biophys Res Commun. 273: 370-6. PMID: 10873613
3. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.  |  Huang, MC., et al. 2000. J Biol Chem. 275: 31353-60. PMID: 10882744
4. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line.  |  Withers, DA. and Hakomori, SI. 2000. J Biol Chem. 275: 40588-93. PMID: 11006292
5. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.  |  Wagers, AJ. and Kansas, GS. 2000. J Immunol. 165: 5011-6. PMID: 11046029
6. Lewis antigen alterations in gastric cancer precursors.  |  Torrado, J., et al. 1992. Gastroenterology. 102: 424-30. PMID: 1732113
7. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.  |  Richman, PI. and Bodmer, WF. 1987. Int J Cancer. 39: 317-28. PMID: 2434440
8. Immunochemical characterization of mucins. Polypeptide (M1) and polysaccharide (A and Leb) antigens.  |  Bara, J., et al. 1988. Biochem J. 254: 185-93. PMID: 2460087
9. First International Workshop on Monoclonal Antibodies against Human Red Blood Cells and Related Antigens. Part I: ABH and other glycoconjugates. Paris, September 21-24, 1987.  |  . 1987. Rev Fr Transfus Immunohematol. 30: 353-717. PMID: 3452881

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group Lewis a Antibody (7LE) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group Lewis a Antibody (7LE) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group Lewis a Antibody (7LE) Specifications

Alternate Product Name: Blood Group Lewis a

Product Clone Name: 7LE

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mucin

Epitope Species: human

Product Reactivity/Detection: Lewis a blood group antigen

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Blood Group Lewis a Antibody (7LE): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin