β3Gn-T7 Antibody (A-4): sc-271739
- β3Gn-T7 Antibody (A-4) is a mouse monoclonal IgG1 κ β3Gn-T7 antibody provided at 200 µg/ml
- raised against amino acids 27-115 mapping near the N-terminus of β3Gn-T7 of human origin
- beta 3Gn-T7 Antibody (A-4) is recommended for detection of β3Gn-T7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-beta 3Gn-T7 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for β3Gn-T7 Antibody (A-4) for WB and IHC(P) applications. These reagents are now offered in bundles with β3Gn-T7 Antibody (A-4) (see ordering information below).
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β3Gn-T7 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects beta 3Gn-T7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β3Gn-T7 (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Beta 3Gn-T7 protein belongs to the beta 1,3-galactosyltransferase family, playing a crucial role in glycosylation processes essential for cell-cell interactions and signaling. β3Gn-T7 functions as an anti-migration factor in lung cancer cell lines, suggesting a potential role in inhibiting tumor metastasis. Research on β3Gn-T7 may provide valuable insights into therapeutic strategies for cancer treatment, particularly in targeting cell migration and invasion mechanisms. Diverse expression patterns of beta 1,3-galactosyltransferase family members underscore the complexity of glycosylation and its implications in various biological processes and diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
β3Gn-T7 Antibody (A-4) References:
- Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. | Shiraishi, N., et al. 2001. J Biol Chem. 276: 3498-507. PMID: 11042166
- beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans. | Seko, A. and Yamashita, K. 2004. FEBS Lett. 556: 216-20. PMID: 14706853
- Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. | Iwai, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 4572-7. PMID: 15755813
- Multiple co-transfection and co-expression of human beta-1,3-N-acetylglucosaminyltransferase with human calreticulin chaperone cDNA in a single step in insect cells. | Deo, VK. and Park, EY. 2006. Biotechnol Appl Biochem. 43: 129-35. PMID: 16277601
- Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. | Marcos, NT., et al. 2008. J Clin Invest. 118: 2325-36. PMID: 18483624
- Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. | Seko, A. and Yamashita, K. 2008. J Biol Chem. 283: 33094-100. PMID: 18826941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β3Gn-T7 Antibody (A-4) | sc-271739 | 200 µg/ml | $322.00 | |||
β3Gn-T7 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-529253 | 200 µg Ab; 10 µg BP | $361.00 | |||
β3Gn-T7 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-522045 | 200 µg Ab, 40 µg BP | $361.00 | |||
β3Gn-T7 Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-543418 | 200 µg Ab; 20 µg BP | $361.00 | |||
β3Gn-T7 Antibody (A-4) AC | sc-271739 AC | 500 µg/ml, 25% agarose | $424.00 | |||
β3Gn-T7 Antibody (A-4) HRP | sc-271739 HRP | 200 µg/ml | $322.00 | |||
β3Gn-T7 Antibody (A-4) FITC | sc-271739 FITC | 200 µg/ml | $336.00 | |||
β3Gn-T7 Antibody (A-4) PE | sc-271739 PE | 200 µg/ml | $349.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 488 | sc-271739 AF488 | 200 µg/ml | $364.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 546 | sc-271739 AF546 | 200 µg/ml | $364.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 594 | sc-271739 AF594 | 200 µg/ml | $364.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 647 | sc-271739 AF647 | 200 µg/ml | $364.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 680 | sc-271739 AF680 | 200 µg/ml | $364.00 | |||
β3Gn-T7 Antibody (A-4) Alexa Fluor® 790 | sc-271739 AF790 | 200 µg/ml | $364.00 |