beta-catenin Antibody (H-2): sc-376805
- beta-catenin Antibody (H-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 755-781 at the C-terminus of β-catenin of human origin
- recommended for detection of β-catenin of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- See beta-catenin (E-5): sc-7963 for beta-catenin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for beta-catenin Antibody (H-2) for WB and IHC(P) applications. These reagents are now offered in bundles with beta-catenin Antibody (H-2) (see ordering information below).
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SEE ALSO...
β-catenin Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that specifically recognizes an epitope mapping between amino acids 755-781 at the C-terminus of human β-catenin. anti-β-catenin antibody (H-2) is validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) across multiple species, including human, mouse, rat, avian, equine, canine, bovine, and porcine. β-catenin, also known as CTNNB1, is a versatile protein central to cell adhesion and Wnt signaling pathways. β-catenin interacts with a variety of proteins, most notably E-cadherin, forming the cadherin-catenin complex at adherens junctions to maintain tissue architecture. β-catenin also binds to the adenomatous polyposis coli (APC) tumor suppressor protein, which regulates its degradation via the ubiquitin-proteasome pathway, and to transcription factors such as TCF/LEF in the nucleus to activate Wnt target genes. Additional interactions include those with axin, a scaffolding protein in the β-catenin destruction complex, and the tyrosine kinase Src, which phosphorylates β-catenin to influence its role in signaling and adhesion. These interactions underline β-catenin′s critical roles in cellular dynamics and signal transduction. β-catenin monoclonal antibody (H-2) is ideal for studying this protein′s interactions and functional versatility in diverse cellular and developmental processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
beta-catenin Antibody (H-2) | sc-376805 | 200 µg/ml | $322.00 | |||
beta-catenin Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-538003 | 200 µg Ab; 10 µg BP | $361.00 | |||
beta-catenin Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-535515 | 200 µg Ab; 40 µg BP | $361.00 | |||
beta-catenin Antibody (H-2): m-IgG2a BP-HRP Bundle | sc-548179 | 200 µg Ab; 10 µg BP | $361.00 | |||
beta-catenin (H-2) Neutralizing Peptide | sc-376805 P | 100 µg/0.5 ml | $69.00 |