beta-catenin Antibody (D-10): sc-133239

β-catenin Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody targeting amino acids 680-781 at the C-terminus of human β-catenin, with proven reactivity to mouse, rat, and human β-catenin across western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. β-catenin, also known as CTNNB1, is a pivotal protein involved in cell adhesion and signaling, characterized by a central armadillo repeat domain flanked by N-terminal and C-terminal regions. The armadillo repeats form a helical structure that mediates protein-protein interactions, enabling β-catenin to bind to E-cadherin at the cell membrane and stabilize adherens junctions. This structure is critical for maintaining tissue architecture and facilitating dynamic cellular behaviors such as migration. The C-terminal domain of β-catenin, targeted by anti-β-catenin antibody (D-10), interacts with transcriptional coactivators during Wnt signaling, where nuclear β-catenin regulates genes involved in development and cancer progression. Structural flexibility within β-catenin also allows formation of complexes with tumor suppressors like APC, highlighting a role in regulating cellular proliferation and tumorigenesis. β-catenin monoclonal antibody (D-10) serves as an essential tool for exploring structural and functional dynamics in adhesion, signaling, and disease mechanisms.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.