β-Arrestin-2 Antibody (D-3): sc-365535

β-Arrestin-2 Antibody (D-3) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect β-Arrestin-2, also known as ARRB2, in human, mouse, and rat species through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β-Arrestin-2 monoclonal antibody (D-3) targets an epitope located between amino acids 385-408 at the C-terminus of the human β-Arrestin-2 protein, ensuring effective binding for reliable detection. β-Arrestin-2 plays a crucial role in regulating G protein-coupled receptor (GPCR) signaling by mediating receptor desensitization, promoting receptor internalization, and initiating alternative signaling pathways independent of G proteins. Structurally, β-Arrestin-2 consists of two seven-bladed beta-propeller domains and an N-terminal domain, which facilitate its interactions with GPCRs and various signaling proteins, thereby enabling its multifunctional role in cellular signaling networks. Post-translational modifications of β-Arrestin-2, such as phosphorylation and ubiquitination, are essential for its ability to regulate receptor trafficking and signal termination, as these modifications modulate its interactions and stability within the cell. Predominantly expressed in neuronal and spleen tissues, β-Arrestin-2 is vital for maintaining cellular homeostasis and regulating responses to extracellular stimuli, influencing processes like neurotransmission, immune responses, and cell migration. Anti-β-Arrestin-2 antibody (D-3) is available in both conjugated and unconjugated forms, providing flexibility for various experimental needs. β-Arrestin-2 (D-3) antibody is recommended for scientists investigating the complex roles of this important protein in health and disease.

The preferred β-Arrestin-2 antibody is β-Arrestin-2 Antibody (H-9): sc-13140.