Bestrophin-2 Antibody (B-5): sc-376660

Bestrophin-2 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects Bestrophin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bestrophin-2, also known as BEST2 or VMD2L1 (Vitelliform macular dystrophy 2-like protein 1), is a 509 amino acid member of the Bestrophin family, which consists of transmembrane proteins characterized by a high percentage of aromatic residues and a conserved RFP (Arg-Phe-Pro) motif, functioning primarily as anion channels. Anti-Bestrophin-2 antibody (B-5) recognizes a protein that plays a crucial role in forming calcium-sensitive chloride channels in the cell membrane, which are essential for maintaining ion homeostasis and facilitating various physiological processes. Bestrophin-2 is predominantly expressed in the retinal pigment epithelium and colon, where Bestrophin-2 contributes to the regulation of fluid transport and electrolyte balance, highlighting its importance in retinal health and gastrointestinal function. Bestrophin-2 channels may also conduct other physiological anions, such as bicarbonate, further underscoring their significance in cellular signaling and homeostasis. Bestrophin-2 (B-5) antibody serves as an invaluable tool for researchers studying the physiological and pathological roles of this important protein.

The preferred Bestrophin-2 antibody is Bestrophin-2 Antibody (D-7): sc-376351.