Bestrophin-2 Antibody (D-7): sc-376351
- Bestrophin-2 Antibody (D-7) is a mouse monoclonal IgG2b κ Bestrophin-2 antibody provided at 200 µg/ml
- raised against amino acids 322-509 mapping at the C-terminus of Bestrophin-2 of human origin
- Bestrophin-2 Antibody (D-7) is recommended for detection of Bestrophin-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Bestrophin-2 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Bestrophin-2 Antibody (D-7) for WB applications. This reagent is now offered in a bundle with Bestrophin-2 Antibody (D-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Bestrophin-2 Antibody (D-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects Bestrophin-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Bestrophin-2 antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Bestrophin-2, also referred to as BEST2 or VMD2L1 (Vitelliform macular dystrophy 2-like protein 1), is a 509 amino acid protein that belongs to the Bestrophin family, which is characterized by transmembrane proteins rich in aromatic residues and a conserved RFP (Arg-Phe-Pro) motif, functioning primarily as anion channels. Bestrophin-2 plays a crucial role in forming calcium-sensitive chloride channels in the cell membrane, which are essential for maintaining ion homeostasis and facilitating various physiological processes. Bestrophin-2 is predominantly expressed in the retinal pigment epithelium and colon, where Bestrophin-2 is involved in the regulation of fluid transport and electrolyte balance, highlighting its importance in retinal health and gastrointestinal function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bestrophin-2 Antibody (D-7) References:
- The vitelliform macular dystrophy protein defines a new family of chloride channels. | Sun, H., et al. 2002. Proc Natl Acad Sci U S A. 99: 4008-13. PMID: 11904445
- Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. | Stöhr, H., et al. 2002. Eur J Hum Genet. 10: 281-4. PMID: 12032738
- Structure-function analysis of the bestrophin family of anion channels. | Tsunenari, T., et al. 2003. J Biol Chem. 278: 41114-25. PMID: 12907679
- Mouse bestrophin-2 is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction. | Qu, Z., et al. 2004. J Gen Physiol. 123: 327-40. PMID: 15051805
- Determinants of anion permeation in the second transmembrane domain of the mouse bestrophin-2 chloride channel. | Qu, Z. and Hartzell, C. 2004. J Gen Physiol. 124: 371-82. PMID: 15452198
- The anion-selective pore of the bestrophins, a family of chloride channels associated with retinal degeneration. | Qu, Z., et al. 2006. J Neurosci. 26: 5411-9. PMID: 16707793
- Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction. | Pifferi, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 12929-34. PMID: 16912113
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bestrophin-2 Antibody (D-7) | sc-376351 | 200 µg/ml | $316.00 | |||
Bestrophin-2 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-522926 | 200 µg Ab, 40 µg BP | $354.00 | |||
Bestrophin-2 Antibody (D-7) AC | sc-376351 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Bestrophin-2 Antibody (D-7) HRP | sc-376351 HRP | 200 µg/ml | $316.00 | |||
Bestrophin-2 Antibody (D-7) FITC | sc-376351 FITC | 200 µg/ml | $330.00 | |||
Bestrophin-2 Antibody (D-7) PE | sc-376351 PE | 200 µg/ml | $343.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 488 | sc-376351 AF488 | 200 µg/ml | $357.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 546 | sc-376351 AF546 | 200 µg/ml | $357.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 594 | sc-376351 AF594 | 200 µg/ml | $357.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 647 | sc-376351 AF647 | 200 µg/ml | $357.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 680 | sc-376351 AF680 | 200 µg/ml | $357.00 | |||
Bestrophin-2 Antibody (D-7) Alexa Fluor® 790 | sc-376351 AF790 | 200 µg/ml | $357.00 |