Bag-2 Antibody (A-7): sc-390262

Bag-2 Antibody (A-7) is a mouse monoclonal IgG2a antibody that detects BAG2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAG2, also known as Bcl-2-associated athanogene 2, plays a crucial role in cellular processes by functioning as a co-chaperone for HSC 70, a heat shock protein that assists in protein folding and protection against stress-induced damage. BAG2 regulates apoptosis and maintains cellular homeostasis, particularly under conditions of stress. BAG2 achieves this by interacting with the HSC 70 ATPase domain and the U-box domain of CHIP, a ubiquitin ligase, thereby modulating the ubiquitination process that tags proteins for degradation. This interaction prevents excessive degradation of proteins essential for cell survival, making BAG2 a key player in cellular response to stress and a potential target for therapeutic interventions in diseases where protein misfolding and apoptosis are involved. Anti-BAG2 antibody (A-7) serves as an invaluable tool for researchers studying protein regulation and cellular stress responses.

The preferred Bag-2 antibody is Bag-2 Antibody (C-6): sc-390107.