BAFF-R Antibody (F-3): sc-365610

BAFF-R Antibody (F-3) is a mouse monoclonal IgG2a antibody that detects BAFF-R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAFF-R, also known as B cell activating factor receptor, plays a pivotal role in the immune system by regulating B cell survival and maturation. BAFF-R is primarily located on the surface of B cells, where BAFF-R interacts with TALL-1 to promote the transition of transitional B cells into mature B cells, which is essential for effective immune responses. Proper functioning of BAFF-R is crucial, as dysregulation can lead to autoimmune diseases or immunodeficiencies. BAFF-R is encoded on chromosome 22q13.1-q13.31 and predominantly expressed in the spleen and lymph nodes, highlighting BAFF-R′s importance in lymphoid tissue and immune function. Anti-BAFF-R antibody (F-3) is an invaluable tool for researchers studying B cell biology and the underlying mechanisms of immune regulation.

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BAFF-R Antibody (F-3) References:

1. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.  |  Ng, LG., et al. 2004. J Immunol. 173: 807-17. PMID: 15240667
2. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency.  |  Losi, CG., et al. 2005. J Clin Immunol. 25: 496-502. PMID: 16160919
3. A novel bioassay for B-cell activating factor (BAFF) based on expression of a BAFF-receptor ectodomain-tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 endodomain fusion receptor in human rhabdomyosarcoma cells.  |  McClements, M., et al. 2008. J Immunol Methods. 337: 63-70. PMID: 18625509
4. Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins.  |  Kohno, T., et al. 2008. Genes Cells. 13: 1061-73. PMID: 18775026
5. Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression.  |  Pahl, MV., et al. 2010. Nephrol Dial Transplant. 25: 205-12. PMID: 19684120
6. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling.  |  Rowland, SL., et al. 2010. J Immunol. 185: 4570-81. PMID: 20861359
7. Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells.  |  Zhou, J., et al. 2013. Nucleic Acids Res. 41: 4266-83. PMID: 23470998
8. BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice.  |  Kyaw, T., et al. 2013. PLoS One. 8: e60430. PMID: 23560095
9. Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers.  |  Figgett, WA., et al. 2015. J Autoimmun. 61: 9-16. PMID: 26027434
10. Novel BAFF-Receptor Antibody to Natively Folded Recombinant Protein Eliminates Drug-Resistant Human B-cell Malignancies In Vivo.  |  Qin, H., et al. 2018. Clin Cancer Res. 24: 1114-1123. PMID: 29180606

The preferred BAFF-R antibody is BAFF-R Antibody (H-1): sc-365410.