BABAM1 Antibody (H-10): sc-398570
- BABAM1 Antibody (H-10) is a mouse monoclonal IgG1 κ BABAM1 antibody provided at 200 µg/ml
- raised against amino acids 191-235 mapping near the C-terminus of BABAM1 of human origin
- BABAM1 Antibody (H-10) is recommended for detection of BABAM1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BABAM1 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BABAM1 Antibody (H-10) for WB applications. These reagents are now offered in bundles with BABAM1 Antibody (H-10) (see ordering information below).
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BABAM1 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects BABAM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BABAM1 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BABAM1 protein, also known as BRISC and BRCA1-A complex member 1, plays a critical role in DNA damage response and cell cycle regulation, making BABAM1 essential for maintaining genomic integrity. Located in cytoplasm and nucleus, BABAM1 is part of BRISC complex, which specifically hydrolyzes ′Lys-63′-linked polyubiquitin chains, a function distinct from other ubiquitin-processing proteases that target ′Lys-48′-linked chains for protein degradation. This unique enzymatic activity is vital for various cellular processes, including signal transduction, DNA repair, and immune responses, as BABAM1 regulates localization, activity, and stability of ubiquitinated proteins without leading them to degradation. BABAM1 interacts with BRCC36 within BRISC complex, enhancing specificity for ′Lys-63′-linked ubiquitin chains, which is particularly important in DNA damage response. BRISC complex, through BABAM1, negatively regulates NF-κB signaling pathway, thereby modulating immune responses. These multifaceted roles underscore BABAM1′s significance in cellular function and potential as a therapeutic target in diseases associated with DNA repair deficiencies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BABAM1 Antibody (H-10) References:
- A fine physical map of the CACNA1A gene region on 19p13.1-p13.2 chromosome. | Trettel, F., et al. 2000. Gene. 241: 45-50. PMID: 10607897
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). | LaPoint, SF., et al. 2000. Adv Anat Pathol. 7: 307-21. PMID: 10976909
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. | Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
- Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. | Buchet-Poyau, K., et al. 2002. Cytogenet Genome Res. 97: 171-8. PMID: 12438709
- The DNA sequence and biology of human chromosome 19. | Grimwood, J., et al. 2004. Nature. 428: 529-35. PMID: 15057824
- Immunogenetics of killer cell immunoglobulin-like receptors. | Parham, P. 2005. Mol Immunol. 42: 459-62. PMID: 15607799
- BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription. | Brocke-Heidrich, K., et al. 2006. Oncogene. 25: 7297-304. PMID: 16732314
- A novel CADASIL-causing mutation in a stroke patient. | Vikelis, M., et al. 2007. Swiss Med Wkly. 137: 323-5. PMID: 17629811
- Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors. | Zimmermann, W., et al. 1988. Cancer Res. 48: 2550-4. PMID: 3356015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BABAM1 Antibody (H-10) | sc-398570 | 200 µg/ml | $316.00 | |||
BABAM1 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-530845 | 200 µg Ab; 10 µg BP | $354.00 | |||
BABAM1 Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-524393 | 200 µg Ab, 40 µg BP | $354.00 | |||
BABAM1 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-544275 | 200 µg Ab; 20 µg BP | $354.00 | |||
BABAM1 Antibody (H-10) AC | sc-398570 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BABAM1 Antibody (H-10) HRP | sc-398570 HRP | 200 µg/ml | $316.00 | |||
BABAM1 Antibody (H-10) FITC | sc-398570 FITC | 200 µg/ml | $330.00 | |||
BABAM1 Antibody (H-10) PE | sc-398570 PE | 200 µg/ml | $343.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 488 | sc-398570 AF488 | 200 µg/ml | $357.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 546 | sc-398570 AF546 | 200 µg/ml | $357.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 594 | sc-398570 AF594 | 200 µg/ml | $357.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 647 | sc-398570 AF647 | 200 µg/ml | $357.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 680 | sc-398570 AF680 | 200 µg/ml | $357.00 | |||
BABAM1 Antibody (H-10) Alexa Fluor® 790 | sc-398570 AF790 | 200 µg/ml | $357.00 |