AVP Antibody (E-8): sc-390723

AVP Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects arginine-vasopressin (AVP) protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-AVP antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Arginine-vasopressin is a crucial neurohypophyseal hormone that plays a significant role in regulating body fluid homeostasis and is also implicated in certain cancers, such as breast cancer, where AVP may function as an autocrine growth factor. AVP precursor is found in various forms, including Neurophysin II and copeptin, and is present in both cell surface and secreted forms in cell lines like Skbr3 and Mcf7. AVP′s location is vital as AVP allows for immediate physiological responses to changes in body fluid levels, with excessive secretion being tightly regulated by hypothalamic osmoreceptors. This regulation is essential because increased AVP levels can lead to elevated mean arterial pressure and systemic vascular resistance, impacting cardiovascular health. AVP′s interaction with V1a and V2 receptors not only influences water retention but also has implications for myocardial function and cancer progression through pathways such as ERK1/2 activation. AVP′s multifaceted roles in both normal physiology and disease processes underscore AVP′s importance as a therapeutic target in conditions like acute and chronic heart failure, as well as AVP′s potential in managing migraine through antinociceptive properties.

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AVP Antibody (E-8) References:

1. Effects of arginine vasopressin (AVP) on the pituitary-thyroid axis in the rat: Evidence that endogenous AVP, acting via V1 receptors, lowers TSH blood concentration.  |  Malendowicz, LK., et al. 2004. Int J Mol Med. 13: 869-72. PMID: 15138627
2. Anatomical and functional evidence for a role of arginine-vasopressin (AVP) in rat olfactory epithelium cells.  |  Levasseur, G., et al. 2004. Eur J Neurosci. 20: 658-70. PMID: 15255977
3. Arginine vasopressin in 316 patients with advanced vasodilatory shock.  |  Luckner, G., et al. 2005. Crit Care Med. 33: 2659-66. PMID: 16276194
4. Vasopressin antagonism in heart failure.  |  Goldsmith, SR. and Gheorghiade, M. 2005. J Am Coll Cardiol. 46: 1785-91. PMID: 16286160
5. Recurrent syncope, hypotension, asthma, and migraine with aura: role of metoclopramide.  |  Gupta, VK. 2005. Headache. 45: 1413-6. PMID: 16324177
6. An N-terminal variant of Trpv1 channel is required for osmosensory transduction.  |  Sharif Naeini, R., et al. 2006. Nat Neurosci. 9: 93-8. PMID: 16327782
7. Enhanced expressions of arginine vasopressin (Avp) in the hypothalamic paraventricular and supraoptic nuclei of type 2 diabetic rats.  |  Yi, SS., et al. 2008. Neurochem Res. 33: 833-41. PMID: 17940875
8. Massive plasma arginine vasopressin (AVP) removal during hemofiltration stimulates AVP secretion in humans.  |  Pruszczynski, W., et al. 1987. J Clin Endocrinol Metab. 64: 383-6. PMID: 3793855
9. Osmotic and non-osmotic regulation of arginine vasopressin (AVP) release, mRNA, and promoter activity in small cell lung carcinoma (SCLC) cells.  |  Kim, JK., et al. 1996. Mol Cell Endocrinol. 123: 179-86. PMID: 8961255
10. Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release.  |  Gomez, F., et al. 1997. J Neurosci Res. 50: 565-74. PMID: 9404718
11. Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies.  |  Keegan, BP., et al. 2006. Breast Cancer Res Treat. 95: 265-77. PMID: 16331351
12. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system.  |  Slusarz, MJ., et al. 2006. Biopolymers. 81: 321-38. PMID: 16333859

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AVP Antibody (E-8) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-AVP Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AVP Antibody (E-8) Specifications

Alternate Product Name: AVP

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 111-160

Epitope Target: AVP

Epitope Species: mouse

Product Reactivity/Detection: AVP precursor, Neurophysin II and copeptin mature chains

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for AVP Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin