ATP10A Antibody (G-9): sc-514650
- ATP10A Antibody (G-9) is a mouse monoclonal IgG2b κ ATP10A antibody provided at 200 µg/ml
- raised against amino acids 1001-1064 mapping near the C-terminus of ATP10A of human origin
- ATP10A Antibody (G-9) is recommended for detection of ATP10A of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ATP10A Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ATP10A Antibody (G-9) for WB applications. These reagents are now offered in bundles with ATP10A Antibody (G-9) (see ordering information below).
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ATP10A Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects ATP10A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATP10A (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ATPase class V type 10A (ATP10A), also known as aminophospholipid translocase VA or probable phospholipid-transporting ATPase VA, is a 1,499 amino acid protein that belongs to the cation transport ATPase (P-type) family. ATP10A is primarily localized to the cell membrane and is widely expressed across various tissues, with the highest expression levels found in the kidney, lung, brain, prostate, testis, ovary, and small intestine. ATP10A plays a crucial role in the transport of phosphatidylserine and phosphatidylethanolamine across the lipid bilayer, which is essential for maintaining membrane asymmetry and cellular signaling. ATP10A function is vital, as defects in this gene can lead to Angelman syndrome, a neurodevelopmental disorder characterized by severe speech and language limitations, movement or balance disorders, and distinctive behavioral traits. The gene encoding ATP10A is an imprinted gene that is maternally expressed, highlighting its significance in genetic regulation and potential implications in developmental biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ATP10A Antibody (G-9) References:
- Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting. | Kayashima, T., et al. 2003. Genomics. 81: 644-7. PMID: 12782135
- On the conflicting reports of imprinting status of mouse ATP10a in the adult brain: strain-background-dependent imprinting? | Kayashima, T., et al. 2003. J Hum Genet. 48: 492-493. PMID: 12955587
- Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. | Kim, KP., et al. 2007. Genome Res. 17: 1731-42. PMID: 17989250
- Association study of the 15q11-q13 maternal expression domain in Japanese autistic patients. | Kato, C., et al. 2008. Am J Med Genet B Neuropsychiatr Genet. 147B: 1008-12. PMID: 18186074
- Gender influences monoallelic expression of ATP10A in human brain. | Hogart, A., et al. 2008. Hum Genet. 124: 235-42. PMID: 18726118
- A multiplex molecular assay for the detection of uniparental disomy for human chromosome 15. | Giardina, E., et al. 2008. Electrophoresis. 29: 4775-9. PMID: 19053076
- Genome-scale network analysis of imprinted human metabolic genes. | Sigurdsson, MI., et al. 2009. Epigenetics. 4: 43-6. PMID: 19218833
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATP10A Antibody (G-9) | sc-514650 | 200 µg/ml | $322.00 | |||
ATP10A Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-524800 | 200 µg Ab, 40 µg BP | $361.00 | |||
ATP10A Antibody (G-9): m-IgG2b BP-HRP Bundle | sc-549186 | 200 µg Ab; 10 µg BP | $361.00 | |||
ATP10A Antibody (G-9) AC | sc-514650 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ATP10A Antibody (G-9) HRP | sc-514650 HRP | 200 µg/ml | $322.00 | |||
ATP10A Antibody (G-9) FITC | sc-514650 FITC | 200 µg/ml | $336.00 | |||
ATP10A Antibody (G-9) PE | sc-514650 PE | 200 µg/ml | $349.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 488 | sc-514650 AF488 | 200 µg/ml | $364.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 546 | sc-514650 AF546 | 200 µg/ml | $364.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 594 | sc-514650 AF594 | 200 µg/ml | $364.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 647 | sc-514650 AF647 | 200 µg/ml | $364.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 680 | sc-514650 AF680 | 200 µg/ml | $364.00 | |||
ATP10A Antibody (G-9) Alexa Fluor® 790 | sc-514650 AF790 | 200 µg/ml | $364.00 |