ASS1 Antibody (C-4): sc-514726
- ASS1 Antibody (C-4) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 373-400 at the C-terminus of ASS1 of human origin
- recommended for detection of ASS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ASS1 Antibody (C-4). This work is in progress.
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ASS1 Antibody (C-4) is a mouse monoclonal IgM antibody that detects ASS1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASS1, also known as argininosuccinate synthase or citrulline-aspartate ligase, plays a crucial role in the urea cycle, catalyzing the second-to-last step in the arginine biosynthetic pathway, which is essential for the detoxification of ammonia in the liver. The protein′s tetrameric structure, composed of identical subunits, is vital for its enzymatic function, as it allows for the proper formation of the active site necessary for substrate binding and catalysis. A deficiency in ASS1 can lead to citrullinemia (CTLN1), an autosomal recessive disorder characterized by severe vomiting and neurological impairments, highlighting the importance of this enzyme in metabolic health. ASS1 (C-4) antibody is an invaluable tool for researchers studying the urea cycle and its associated disorders, providing insights into ASS1 expression and function in various biological contexts.
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ASS1 Antibody (C-4) References:
- Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations. | Diez-Fernandez, C., et al. 2017. Hum Mutat. 38: 471-484. PMID: 28111830
- Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors. | Keshet, R., et al. 2020. Nat Cancer. 1: 894-908. PMID: 35121952
- FXR/ASS1 axis attenuates the TAA-induced liver injury through arginine metabolism. | Hong, W., et al. 2022. Biochem Biophys Res Commun. 611: 31-37. PMID: 35477090
- PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway. | Liu, M., et al. 2022. Mol Oncol. 16: 2843-2860. PMID: 35674458
- Asymptomatic ASS1 carriers with high blood citrulline levels. | Chen, HA., et al. 2022. Mol Genet Genomic Med. 10: e2007. PMID: 35726796
- ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells. | Hu, Q., et al. 2023. Cancer Res. 83: 1646-1665. PMID: 36892426
- β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer. | Wang, H., et al. 2024. Free Radic Biol Med. 214: 137-157. PMID: 38364944
- ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis. | Luo, W., et al. 2024. Cell Death Dis. 15: 319. PMID: 38710705
- ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. | Lim, LQJ., et al. 2024. Nat Metab. 6: 1294-1309. PMID: 38858597
- ASS1 enhances anoikis resistance via AMPK/CPT1A-mediated fatty acid metabolism in ovarian cancer. | Feng, X., et al. 2024. Cancer Lett. 217082. PMID: 38914306
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASS1 Antibody (C-4) | sc-514726 | 200 µg/ml | $322.00 | |||
ASS1 (C-4) Neutralizing Peptide | sc-514726 P | 100 µg/0.5 ml | $69.00 |