ASS1 Activators
The class of ASS1 activators encompasses a diverse array of chemicals that play crucial roles in modulating the activity of argininosuccinate synthase 1 (ASS1). One of the direct activators is L-Citrulline, a substrate for ASS1 that facilitates the production of L-arginine, a key player in nitric oxide synthesis. L-Citrulline's direct activation involves providing ASS1 with the necessary precursor for efficient enzymatic activity, contributing to the regulation of nitric oxide production. Another direct activator, L-Arginine, serves as a substrate for ASS1, directly influencing the enzymatic activity of ASS1. Through its conversion into nitric oxide and ornithine, L-Arginine plays a crucial role in the urea cycle, exemplifying direct activation by providing ASS1 with a key substrate. Nitric oxide donors, represented by sodium nitroprusside, provide a different mechanism of direct activation. These compounds release nitric oxide, mimicking the physiological activation of ASS1 and contributing to the regulation of various processes, including vascular tone and immune response.
Several chemicals act as indirect activators of ASS1. Sodium bicarbonate creates a favorable alkaline environment, indirectly enhancing ASS1 activity by modulating the microenvironment around the enzyme. N-Acetylglutamate, acting as a cofactor, indirectly activates ASS1 by promoting efficient substrate binding and catalysis in the urea cycle. Ornithine alpha-ketoglutarate indirectly activates ASS1 by providing ornithine, enhancing the availability of this substrate for the urea cycle. Arginase inhibitors, such as Nω-Hydroxy-L-arginine, indirectly activate ASS1 by preventing the breakdown of L-arginine, increasing its availability for nitric oxide synthesis. Calcium channel modulators, like Amlodipine, indirectly activate ASS1 by influencing intracellular calcium levels. Glucagon and insulin, through cAMP-dependent and PI3K/Akt signaling pathways, respectively, indirectly activate ASS1 by modulating downstream events that impact ASS1 activity. Furthermore, glutamate indirectly activates ASS1 by influencing the production of N-acetylglutamate, a cofactor for ASS1. Spermidine, through the promotion of N-acetylglutamate synthesis, also indirectly activates ASS1, contributing to the efficient metabolism of ammonia in the urea cycle.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Citrulline | 372-75-8 | sc-204784 sc-204784A | 5 g 200 g | $31.00 $235.00 | ||
L-Citrulline activates ASS1 directly by providing a substrate for the enzymatic reaction. It is converted to L-arginine in the presence of ASS1, leading to the activation of ASS1 and facilitating the production of nitric oxide. This direct activation involves L-Citrulline acting as a precursor for the synthesis of L-arginine, a key substrate for ASS1-mediated nitric oxide production. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine serves as a direct activator of ASS1 by being a substrate for the enzyme. Through its conversion into nitric oxide and ornithine, L-Arginine activates ASS1, playing a crucial role in the urea cycle and nitric oxide synthesis. This direct activation involves L-Arginine serving as a substrate for ASS1, leading to the modulation of the enzyme's activity and subsequent physiological effects in nitric oxide production and urea cycle metabolism. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $20.00 $28.00 $42.00 $82.00 $683.00 | 1 | |
Sodium bicarbonate activates ASS1 indirectly by providing a favorable alkaline environment. The increased pH enhances the activity of ASS1, leading to improved catalysis in the urea cycle. This indirect activation involves the modulation of the microenvironment around ASS1, facilitating its enzymatic activity and promoting efficient urea cycle function. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
N-α-Acetyl-L-glutamine activates ASS1 indirectly by acting as a cofactor. It enhances ASS1 activity by binding to the enzyme, promoting substrate binding and catalysis in the urea cycle. This indirect activation involves N-Acetylglutamate serving as a cofactor, modulating ASS1 activity and contributing to the efficient metabolism of ammonia in the urea cycle. | ||||||
L-Ornithine-α-ketoglutarate | 5191-97-9 | sc-475792 | 100 g | $32.00 | ||
Ornithine alpha-ketoglutarate activates ASS1 indirectly by providing ornithine, a substrate for the urea cycle. It enhances the availability of ornithine, promoting ASS1 activity and contributing to efficient ammonia metabolism. This indirect activation involves Ornithine alpha-ketoglutarate influencing the urea cycle, leading to the modulation of ASS1 activity and facilitating the metabolism of ammonia. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin indirectly activates ASS1 by influencing PI3K/Akt signaling pathways. Through the activation of Akt, insulin enhances ASS1 activity, contributing to the regulation of the urea cycle. This indirect activation involves insulin-mediated signaling events that impact ASS1 activity and contribute to the efficient metabolism of ammonia in the urea cycle. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate indirectly activates ASS1 by providing a substrate for the production of N-acetylglutamate. N-acetylglutamate is a cofactor for ASS1, and its synthesis is influenced by glutamate availability. This indirect activation involves the modulation of N-acetylglutamate levels, impacting ASS1 activity and contributing to the regulation of the urea cycle. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine indirectly activates ASS1 by promoting the synthesis of N-acetylglutamate, a cofactor for ASS1. The increased availability of N-acetylglutamate enhances ASS1 activity, contributing to the regulation of the urea cycle. This indirect activation involves the modulation of N-acetylglutamate levels, impacting ASS1 activity and contributing to the efficient metabolism of ammonia in the urea cycle. | ||||||