Aspartoacylase-3 Antibody (D-4): sc-390434

Aspartoacylase-3 Antibody (D-4) is a mouse monoclonal IgG2a antibody that detects Aspartoacylase-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aspartoacylase-3, also known as aminoacylase-3, is a 319 amino acid protein primarily expressed in the proximal tubules of the kidney, where Aspartoacylase-3 plays a crucial role in the deacetylation of mercapturic acids, thereby contributing to the detoxification processes in renal function. Aspartoacylase-3 localizes to the cytoplasm of S2 and S3 proximal tubules, as well as the apical domain of S1 proximal tubules, highlighting Aspartoacylase-3′s involvement in renal metabolism and potential interactions with other renal proteins. Aspartoacylase-3 is expressed at lower levels in various tissues, including the stomach, testis, heart, brain, lung, and liver, and may also function as a core binding protein for the Hepatitis C virus, indicating Aspartoacylase-3′s potential role in viral pathogenesis. The gene encoding Aspartoacylase-3 is located on human chromosome 11, a region associated with several genetic disorders, underscoring Aspartoacylase-3′s importance in both health and disease. Anti-Aspartoacylase-3 antibody (D-4) is an essential tool for researchers investigating the functional dynamics of this protein in various biological contexts.

The preferred Aspartoacylase-3 antibody is Aspartoacylase-3 Antibody (A-5): sc-393862.