ARP-1 Antibody (D-12): sc-271264
- ARP-1 Antibody (D-12) is a mouse monoclonal IgG1 (lambda light chain) provided at 200 µg/ml
- specific for an epitope mapping between amino acids 13-44 at the N-terminus of ARP-1 of human origin
- recommended for detection of ARP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-271264 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ARP-1 Antibody (D-12) for WB applications. These reagents are now offered in bundles with ARP-1 Antibody (D-12) (see ordering information below).
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SEE ALSO...
ARP-1 Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects ARP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARP-1, also known as COUP-TFII, plays a crucial role in various biological processes, particularly in gene expression regulation during development. ARP-1 is primarily located in the nucleus, where ARP-1 functions as a transcription factor, influencing the expression of genes involved in cellular differentiation and development. Nuclear localization of ARP-1 enables interaction with specific DNA response elements, thereby modulating target gene transcription. ARP-1 interacts with other transcription factors, such as retinoic acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR), which underscores ARP-1′s importance in coordinating complex regulatory networks that govern cellular functions. ARP-1′s ability to act as both a negative regulator and transcription initiator highlights ARP-1′s versatile role in cellular signaling pathways, making ARP-1 a significant focus of research in developmental biology and disease mechanisms.
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ARP-1 Antibody (D-12) References:
- ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. | Kang, S., et al. 2003. J Biol Chem. 278: 30478-86. PMID: 12777384
- Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid. | Widom, RL., et al. 1992. Mol Cell Biol. 12: 3380-9. PMID: 1321332
- Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. | Ladias, JA. and Karathanasis, SK. 1991. Science. 251: 561-5. PMID: 1899293
- ARP-1 Regulates the Transcriptional Activity of the Aromatase Gene in the Mouse Brain. | Honda, SI. and Harada, N. 2020. Front Endocrinol (Lausanne). 11: 306. PMID: 32582022
- Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain. | Lopes da Silva, S., et al. 1995. Brain Res Mol Brain Res. 30: 131-6. PMID: 7609634
- Transcriptional activation by the orphan nuclear receptor ARP-1. | Malik, S. and Karathanasis, S. 1995. Nucleic Acids Res. 23: 1536-43. PMID: 7784207
- A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. | Ben-Shushan, E., et al. 1995. Mol Cell Biol. 15: 1034-48. PMID: 7823919
- Transcriptional repression of apolipoprotein AI gene expression by orphan receptor ARP-1. | Ge, R., et al. 1994. J Biol Chem. 269: 13185-92. PMID: 8175747
- The ARP-1 orphan receptor represses steroid-mediated stimulation of human placental lactogen gene expression. | Stephanou, A., et al. 1996. J Mol Endocrinol. 16: 221-7. PMID: 8782080
- Functional domains of the human orphan receptor ARP-1/COUP-TFII involved in active repression and transrepression. | Achatz, G., et al. 1997. Mol Cell Biol. 17: 4914-32. PMID: 9271371
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARP-1 Antibody (D-12) | sc-271264 | 200 µg/ml | $322.00 | |||
ARP-1 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-540220 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARP-1 Antibody (D-12): m-IgG1 BP-HRP Bundle | sc-541979 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARP-1 (D-12) Neutralizing Peptide | sc-271264 P | 100 µg/0.5 ml | $69.00 | |||
ARP-1 Antibody (D-12) X | sc-271264 X | 200 µg/0.1 ml | $322.00 |